国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (4): 312-315.

• 综述 • 上一篇    下一篇

DNA甲基化在卵巢癌中的研究进展

王文文, 邱丽华

  

  1. 上海交通大学医学院附属仁济医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-07-15 发布日期:2012-07-15
  • 通讯作者: 邱丽华

Current Review on DNA Methylation in Ovarian Cancer

WANG Wen-wen，QIU Li-hua   

  1. Department of Obstetrics and Gynecology，Renji Hospital，Shanghai Jiaotong University School of Medicine，Shanghai 200127，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-07-15 Online:2012-07-15
  • Contact: QIU Li-hua

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摘要： 卵巢癌是妇科常见恶性肿瘤之一，病死率居妇科肿瘤之首。因早期多无明显症状体征且缺乏敏感和特异的筛选手段，70%以上的患者发现时已为晚期，多伴有腹水、盆腹腔广泛转移，恶性程度高，预后极差，故卵巢癌的早发现早诊断在提高生存率方面显得尤为重要。近年表观遗传学的研究进展迅速，在卵巢癌发生发展治疗等方面具有重要的指导意义，为卵巢癌的早期诊断、优化治疗、改善预后指明新方向。DNA甲基化是最常见也是目前研究最清楚的表观遗传修饰形式，能引起染色质结构、DNA构象、DNA稳定性及DNA与蛋白质相互作用方式的改变，调控基因表达，在肿瘤的发生发展中扮演重要角色。就DNA甲基化在卵巢癌表观遗传学中的研究进展作一综述。

关键词: 后成说, 遗传, DNA甲基化, 卵巢肿瘤, 基因, CpG岛

Abstract: Ovarian cancer is one of the common gynecologic neoplasms，which is ranked the most lethal among gynecological cancers in women. Since lacking of obvious clinical symptoms and effective early diagnostic methods for screening，more than 70% of patients are diagnosed at the advanced stage always accompanied with ascites and abdominal widespread metastasis. The prognosis in those patients is poor. Therefore，it is particularly important to improve the survival rate of ovarian cancer by early detection and early diagnosis. In recent years，rapid progresses in epigenetics make a great significance for early diagnosis，new treatment and better prognosis of ovarian cancer. DNA methylation，the most common form of epigenetic modification，can lead to many changes，such as chromatin structure，DNA conformation，DNA stability and interaction between DNA and protein. The epigenetic modification could change gene expression，which plays an important role in the formation and progression of ovarian cancer.

Key words: Epigenesis, genetic, DNA methylation, Ovarian neoplasms, Genes, CpG islands