国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (6): 455-457.

• 综述 • 上一篇    下一篇

体外受精-胚胎移植中年轻患者卵巢低反应的促排卵方案选择

张文香,姜 宏   

  1. 230031 合肥，安徽医科大学解放军临床学院生殖中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-11-15 发布日期:2012-11-15
  • 通讯作者: 姜 宏

The Options in the Management of Young Poor Responders in In-vitro Fertilization

ZHANG Wen-xiang，JIANG Hong   

  1. Reproductive Medicine Center，the Clinical College of PLA Affiliated Anhui Medical University，Hefei 230031，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-11-15 Online:2012-11-15
  • Contact: JIANG Hong

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摘要： 促排卵方案的正确选择关系到卵巢低反应者所获卵母细胞的数量和质量，通过评估卵巢储备功能预测卵巢反应性，从而采取有效的个体化超促排卵方案增加卵巢对促性腺激素的反应性，提高妊娠率。虽然目前有多种治疗方案可供选择，如促性腺激素释放激素激动剂（GnRHa）短方案、促性腺激素释放激素拮抗剂（GnRHA）方案、微刺激方案、自然周期和未成熟卵体外培养成熟（IVM）技术等，但对各种方案的利弊还未形成清晰、统一的认识，还需要进行多中心大样本前瞻性随机临床对照研究。

关键词: 超排卵, 受精, 体外, 胚胎移植, 卵巢低反应, 卵巢刺激方案

Abstract: The quantity and quality of oocytes could be improved by the ideal stimulation protocol for poor responders. The prediction of compromised response prior to cycle initiation by a thorough assessment of ovarian reserve could allow a more appropriate selection of controlled ovarian hyperstimulation protocols for each individual patient. Several strategies have been proposed for clinical management of poor responders, such as gonadotropin-releasing hormone agonist short protocol, gonadotropin-releasing hormone antagonist protocol, milder ovarian stimulation, nature cycle and in vitro maturation, but the so-called ideal stimulation protocol still remains a challenge. So, the randomized controlled prospective trials with large samples are necessary.

Key words: Superovulation, Fertilization in vitro, Embryo transfer, Poor ovarian response, Ovarian stimulation protocols