国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (1): 50-54.

• 综述 • 上一篇    下一篇

邻苯二甲酸二辛酯对哺乳动物生殖系统影响的研究进展


周婉格, 王统菲, 周 任, 丁之德
  

  1. 200025 上海交通大学医学院临床医学系(周婉格,王统菲,周 任),人体组织胚胎学教研室(丁之德)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-01-15 发布日期:2013-01-15
  • 通讯作者: 丁之德

Effects of Di(2-ethylhexyl) phthalate (DEHP) on Mammalian Reproductive System: A Review

ZHOU Wan-ge,WANG Tong-fei,ZHOU Ren,DING Zhi-de   

  1. Department of Clinical Medicine(ZHOU Wan-ge,WANG Tong-fei,ZHOU Ren),Department of Human Histology and Embryology(DING Zhi-de),School of Medicine,Shanghai Jiao Tong University,Shanghai 200025,China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-01-15 Online:2013-01-15
  • Contact: DING Zhi-de

摘要: 许多工业产品中都含邻苯二甲酸二辛酯(DEHP)这一化学成分,近年来发现其对哺乳动物生殖系统有着严重的毒副作用,且在雄性和雌性的发育中均有表现。哺乳动物生殖系统发育涉及多种激素和基因的调节,而DEHP可对其中的某些关键性环节产生干扰作用。研究DEHP毒理的发生及作用机制,将对生殖系统疾病的预防、诊断及治疗具有重要的临床意义。

关键词: 哺乳动物, 二乙基己基邻苯二甲酸, 男(雄)性泌尿生殖系统疾病, 女(雌)性泌尿生殖系统疾病

Abstract: DEHPs,chemicals contained abundantly in many industrial products,had severe adverse effects on mammalian reproductive system involved in both male and female development. The development of mammalian reproductive system is related to a variety of hormones and the regulation of genes. DEHPs could interfer the key steps of hormone metabolism or gene expression. This review focused on the toxic effects of DEHP,and its mechanism,which is important for clinic to prevent,diagnose and treat the diseases of reproductive system.

Key words: Mammals, Diethylhexyl phthalate, Male urogenital diseases, Female urogenital diseases