国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (3): 194-197.

• 综述 • 上一篇    下一篇

高雄激素致多囊卵巢综合征发病机制的研究进展


王芳芳, 潘洁雪, 任 珺, 黄荷凤   

  1. 310006 杭州，浙江大学医学院附属妇产科医院生殖内分泌科（王芳芳，潘洁雪，黄荷凤）；浙江大学医学院教育部生殖遗传重点实验室（任 珺）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-05-15 发布日期:2013-05-15
  • 通讯作者: 黄荷凤

Hyperandrogenism Involved in Pathogenesis of Polycystic Ovary Syndrome

WANG Fang-fang，PAN Jie-xue，REN Jun，HUANG He-feng   

  1. Department of Reproductive Endocrinology，Women′s Hospital，School of Medicine，Zhejiang University，Hangzhou 310006，China（WANG Fang-fang，PAN Jie-xue，HUANG He-feng）；Key Laboratory of Reproductive Genetics，Ministry of Education of China，Hangzhou 310006，China（REN Jun）
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-05-15 Online:2013-05-15
  • Contact: HUANG He-feng

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摘要： 多囊卵巢综合征（polycystic ovary syndrome，PCOS）是高雄激素性不排卵性不孕的最常见原因，在育龄女性中的发生率高达10%。其主要表现为稀发排卵、高雄激素血症或临床高雄激素症状及卵巢呈多囊样改变等。因其临床表现的异质性，迄今为止发病机制尚未完全阐明。然而，高雄激素暴露在PCOS发病过程中所起的关键作用已在世界范围内得到公认，并且近年来的研究强调了胎儿期编程学说和表观遗传学的重要性。综述雄激素在卵巢中的生理功能及其在PCOS发病中可能机制的研究进展。

关键词: 雄激素类, 多囊卵巢综合征, 胎儿期疗法, 遗传学, 医学

Abstract: Polycystic ovary syndrome（PCOS） is the most common cause of hyperandrogenic anovulatory infertility，with the incidence of 10% among women of reproductive age. The main manifestations include ovulation，hyperandrogenism and polycystic ovary. Since its clinical manifestations are heterogeneous，the etiology of PCOS is still unclear. Nevertheless，the crucial role of hyperandrogenism in PCOS pathogenesis has been recognized in the world. Recently，scientists paid more attention on the early developmental origin hypothesis and epigenetics. We reviewed the role of androgen in ovarian function and its potential mechanism in PCOS pathogenesis.

Key words: Androgens, Polycystic ovary syndrome, pathogenesis, Fetal therapies, Genetics, medical