国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (5): 409-411.

• 综述 • 上一篇    下一篇

与多囊卵巢综合征患者子宫内膜容受性相关的蛋白分子

李爱杰, 杨雪峰   

  1. 450052 郑州大学第三附属医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-09-15 发布日期:2013-09-15

Progress of Study on Endometrial Receptivity at Molecular Level of the Polycystic Ovary Syndrome

LI Ai-jie，YANG Xue-feng   

  1. Department of Obstetrics and Gynecology，the Third Affiliated Hospital of Zhengzhou University，Zhengzhou 450052，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-09-15 Online:2013-09-15

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摘要： 多囊卵巢综合征（PCOS）是一种育龄妇女常见的内分泌疾病，多数患者因育龄期不孕就诊。PCOS患者经过药物治疗纠正内分泌紊乱、恢复正常排卵后仍有低妊娠率和高流产率，这可能是由于长期的激素失调使子宫内膜容受性下降所致。国内外大量文献研究表明，透明质酸（HA）、黏蛋白（MUC1）、钙黏附蛋白（E-cadherin）、G蛋白耦联雌激素受体（GPER）等分子均在子宫内膜周期性表达，并在不孕患者子宫内膜异常表达，提示HA、MUC1、E-cadherin、GPER与子宫内膜容受性有关。综述这4类蛋白分子与PCOS患者子宫内膜容受性关系的研究进展

关键词: 多囊卵巢综合征, 子宫内膜, 细胞黏附分子, 抗原, CD44, 钙黏着糖蛋白类

Abstract: Polycystic ovarian syndrome(PCOS) is a common endocrine disease in women of childbearing age. Most of patients with PCOS visit doctors because of their infertility. Patients with PCOS still have the high rate of abortion and low rate of pregnancy, although their ovulation and endocrine have been adjusted by drug treatment, which is mostly due to the lowered endometrial receptivity induced by long term of hormonal imbalance. It was shown that HA, MUC1, E-cadherin and GPER cyclically expressed in endometrium, and that expressions of these proteins were abnormal in endometrium of patients with infertility. It suggested that HA, MUC1, E-cadherin and GPER were bound up with endometrial receptivity. In this paper, roles of these factors were reviewed in the lowered endometrial receptivity of PCOS.

Key words: Polycystic ovary syndrome, Endometrium, Cell adhesion molecules, Antigens, CD44, Cadherins