国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2014, Vol. 33 ›› Issue (1): 52-55.

• 综述 • 上一篇    下一篇

微小RNA在子宫内膜容受性中的表达与调控

胡玉琴，沙爱国   

  1. 361000 福建省厦门市，安徽医科大学解放军174临床学院（胡玉琴）；中国人民解放军174医院生殖医学中心（沙爱国）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-01-15 发布日期:2014-01-15
  • 通讯作者: 沙爱国

Expression and Regulation of microRNAs in Endometrial Receptivity

HU Yu-qin，SHA Ai-guo   

  1. Department of Clinical College in No.174 Hospital of PLA，Anhui Medical University，Xiamen 361000，Fujian Province，China（HU Yu-qin）；Reproductive Medicine Center of No.174 Hospital of PLA，Xiamen 361000，Fujian Province，China（SHA Ai-guo）
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-01-15 Online:2014-01-15
  • Contact: SHA Ai-guo

PDF (PC)

7471

摘要： 子宫内膜容受性是指子宫内膜对胚胎的接受能力，只有处于容受期的内膜才允许胚泡黏附侵入。而容受期的建立和维持受很多分子及基因的调控，近年来微小RNA（miRNA）对子宫内膜容受性的调控作用日益受到关注。多个研究利用高通量表达分析的手段分析了自然月经周期和超促排卵周期等不同容受状态的子宫内膜，发现miRNA均表现出特征性的表达变化，初步揭示了miRNA作为子宫内膜容受性标记物的潜力。作为调节基因表达的转录后调节因子，miRNA对子宫内膜容受性的调节主要体现在对与容受性相关的关键基因和通路的表达调节上。

关键词: 微RNAs, 胚胎植入, 子宫内膜, 子宫内膜容受性

Abstract: The endometrial receptivity is a temporal status of endometrium which posses the receptive ability to embryonic implantation. Only in the receptive phase，the endometrium allows embryo to attach and penetrate. It is regulated by many factors and genes to establish and maintain the endometrial receptivity. Recently，there is a growing interest in the role of microRNAs （miRNAs） in regulating the endometrium receptivity. With the high-throughout expression analytical methods，several studies have found some characteristics of miRNAs expressed in the endometrium of different receptive status，including the natural menstrual cycle and the stimulated cycle. Those preliminary results showed miRNAs as potential markers of the endometrium receptivity. As important post-transcriptional regulators of gene expression，miRNAs exert their functions through regulating the expression of key genes and pathways involved in the embryo implantation.

Key words: MicroRNAs, Embryo implantation, Endometrium, Endometrial receptivity