国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2014, Vol. 33 ›› Issue (3): 205-208.

• 综述 • 上一篇    下一篇

辅助生殖技术子代的围生结局研究进展

钱春凤，高靓，李红   

  1. 215002 江苏省苏州市，南京医科大学附属苏州医院生殖与遗传中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-05-15 发布日期:2014-05-15
  • 通讯作者: 李红

Perinatal Outcomes of Offsprings from Assisted Reproductive Technology：a Review

QIAN Chun-feng，GAO Liang，LI Hong   

  1. Center for Reproduction and Genetics，Nanjing Medical University Affiliated Suzhou Hospital，Suzhou 215002，Jiangsu Province，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-05-15 Online:2014-05-15
  • Contact: LI Hong

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摘要： 辅助生殖技术（assisted reproductive technology，ART）作为不孕症治疗的有效方法正在被广泛应用。随着ART子代人数的增加，ART的安全性引起更多关注。多胎妊娠发生率的增加使ART子代伴有更多围生风险，但排除多胎妊娠后，ART单胎子代同自然妊娠子代比较仍具有稍高的早产率、低出生体质量率及先天畸形率等围生结局。其机制目前尚不明确，潜在的不孕背景、ART操作、促排卵可能是引起ART子代不良围生结局的原因。优生优育指导、必要的产前筛查及诊断有利于改善ART子代围生结局。综述ART子代围生结局研究进展，了解ART的安全性。

关键词: 殖技术, 辅助, 妊娠结局, 早产, 婴儿, 出生时低体重, 先天畸形

Abstract: The assisted reproductive technology（ART） as an effective method of infertility treatment is widely used in the world. With increasing ART offsprings，the long-term security of ART gets more attention. Multiple pregnancy is associated with adverse perinatal outcomes. Besides, growing evidence showed that ART singletons had the increased risks of preterm birth （PTB） and low birthweight, and an increased rate of congenital malformations. The mechanism is not yet clear, however the infertility background，ART procedures and ovarian stimulation may be potential cause of adverse perinatal outcomes of ART offsprings. Counseling for genetics, good birth and good care, and the preimplantation genetic screening（PGS） or prenatal diagnosis if necessary should be used to improve perinatal outcomes of ART offsprings. In this review, we discussed the ART security and perinatal outcomes of ART offsprings.

Key words: Reproductive technology, assisted, Pregnancy outcomes, Premature birth, Infant, low birth weight, Congenital abnormalities