国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2014, Vol. 33 ›› Issue (4): 297-300.

• 综述 • 上一篇    下一篇

微小RNA与宫颈癌

李圃，刘俊燕，孔凡铭，尹利荣   

  1. 300100 天津中心妇产科医院妇瘤科（李圃）；天津医科大学病原生物学系（刘俊燕）；天津中医药大学第一附属医院肿瘤科（孔凡铭）；天津医科大学第二医院妇产科（尹利荣
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-07-15 发布日期:2014-07-15
  • 通讯作者: 尹利荣

MicroRNA and Cervical Cancer

LI Pu，LIU Jun-yan，KONG Fan-ming，YIN Li-rong   

  1. Department of Gynecologic Oncology，Tianjin Central Hospital of Gynecology Obstetrics，Tianjin 300100，China（LI Pu）；Department of Pathogeny Biology，Tianjin Medical University，Tianjin 300070，China（LIU Jun-yan）；Department of Oncology，First Teaching Hospital of Tianjin University of TCM，Tianjin 300193，China（KONG Fan-ming）；Department of Obstetrics and Gynecology，The Second Hospital of Tianjin Medical University，Tianjin 300210，China（YIN Li-rong）
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-07-15 Online:2014-07-15
  • Contact: YIN Li-rong

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摘要： 微小RNA（microRNA，miRNA）是一类内源性非编码调节性小RNA，通过与3′非转录区（3′UTR）互补配对来调节其靶基因的蛋白翻译或者mRNA降解过程，从而在转录后水平调节靶基因的表达。成熟的miRNA通过调节靶基因的表达行使其生物学功能，参与细胞增长、细胞凋亡等多种细胞癌变过程。研究表明，miRNA在宫颈癌中的差异性表达有可能使其成为诊断、临床病理学特征和评价预后的新指标。miRNA也可以用于指导治疗以及成为治疗用药的靶点，为临床应用提供广泛前景。

关键词: 微RNAs, 宫颈肿瘤, 癌, 诊断, 抗药性, 肿瘤

Abstract: MicroRNA （miRNA）, a class of endogenous small non-coding regulatory RNAs, regulate the expression of target genes by pairing with its 3′untranslated regions （3′UTR） to induce the inhibited translation or mRNA degression. Mature miRNA may interfere with multiple biological processes involved in tumorigenesis such as cell proliferation, cell cycle, apoptosis, angiogenesis, invasion and metastasis. Multiple studies showed that the aberrant expression of miRNA, as novel potential makers, could provide numerous promising merits in diagnostic, pathological and therapeutic targets in cervical cancer.

Key words: MicroRNAs, Uterine cervical neoplasms, Carcinoma, Diagnosis, Drug resistance, neoplasm