宫颈淋巴上皮癌一例

doi:10.12280/gjszjk.20250608

摘要/Abstract

摘要：

宫颈淋巴上皮癌（lymphoepithelioma-like carcinoma，LEC）是一种罕见的宫颈恶性肿瘤，其发病机制尚不明确。报告1例49岁女性患者，因人乳头瘤病毒16（human papillomavirus 16，HPV16）感染及同房后接触性出血就诊，阴道镜下活检组织病理诊断为乳头状鳞癌，遂行免举宫腹腔镜下经腹广泛性子宫切除术+双侧附件切除术+双侧卵巢动静脉高位结扎术+盆腔淋巴结清扫术+肿瘤化学药物治疗（术中注射用洛铂50 mg腹腔灌注化疗），术后经病理组织活检及免疫组织化学检查确诊为宫颈LEC。术后辅以紫杉醇白蛋白+卡铂化疗共6个周期。随访至2025年11月22日未见复发及转移。提示，在HPV感染相关性宫颈肿瘤中，应警惕宫颈LEC的可能，病理及免疫组织化学检查对明确诊断具有重要价值，规范的手术治疗联合辅助化疗可能有助于改善预后。

关键词: 宫颈肿瘤, 癌, 淋巴上皮癌, 人乳头瘤病毒16, 诊断, 治疗

Abstract:

Cervical lymphoepithelioma-like carcinoma (LEC) is a rare malignant tumor of the cervix, and its pathogenesis is still unclear. We report a case of 49-year-old female patient who presented with human papillomavirus 16 (HPV 16) infection and post-coital hemorrhage. She was diagnosed as papillary squamous cell carcinoma by histopathological biopsy under colposcope. She underwent laparoscopic transabdominal hysterectomy without uterine manipulator+bilateral adnexectomy+bilateral ovarian arteriovenous high ligation+pelvic lymph node dissection + tumor chemotherapy (intraperitoneal infusion of lobaplatin 50 mg). After surgery, she was diagnosed as cervical LEC by pathology and immunohistochemistry. The postoperative chemotherapy of adjuvant paclitaxel albumin+carboplatin was for a total of 6 cycles. No recurrence or metastasis was found through the follow-up until November 22, 2025. This case suggests that in HPV infection-related cervical tumors, the possibility of cervical LEC should be alerted. Pathological and immunohistochemical examinations are of great value in clarifying the diagnosis. Standardized surgical treatment combined with adjuvant chemotherapy may improve the prognosis of patients.

Key words: Uterine cervical neoplasms, Carcinoma, Lymphoepithelioma-like carcinoma, Human papillomavirus 16, Diagnosis, Therapy

令菲菲, 王思瑶, 李红丽, 刘畅. 宫颈淋巴上皮癌一例[J]. 国际生殖健康/计划生育杂志, 2026, 45(2): 125-129.

LING Fei-fei, WANG Si-yao, LI Hong-li, LIU Chang. Lymphoepithelioma-Like Carcinoma of the Cervix: A Case Report[J]. Journal of International Reproductive Health/Family Planning, 2026, 45(2): 125-129.

图/表 2

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