国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2014, Vol. 33 ›› Issue (6): 434-437.

• 综述 • 上一篇    下一篇

间质细胞增殖的睾丸内局部调节因子

代晓南，徐文丹，崔毓桂   

  1. 210029 南京医科大学第一附属医院生殖医学科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-11-15 发布日期:2014-11-15
  • 通讯作者: 崔毓桂

Local Factors Regulating Proliferation of Testicular Leydig Cells

DAI Xiao-nan, XU Wen-dan, CUI Yu-gui   

  1. Clinical Center of Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-11-15 Online:2014-11-15
  • Contact: CUI Yu-gui

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摘要： 睾丸间质细胞是男性体内合成雄激素的主要组织细胞。胎儿期睾丸间质细胞从间质前体细胞分化形成，出生后出现由间质干细胞分化形成的第二代睾丸间质细胞，青春期的间质细胞则是由多能间质前体细胞分化而来，经历前体睾丸间质细胞、不成熟睾丸间质细胞、成熟睾丸间质细胞3个不连续的成熟阶段。胎儿期及出生后间质细胞的分化、增殖、发育受多种因素的调节，包括性别决定基因Y、神经细胞黏附分子、转化生长因子、抗苗勒管激素（AMH）等调节；出生后的睾丸间质细胞增殖、发育、成熟除受黄体生成激素调节外，受睾丸局部的雄激素、胰岛素样生长因子1（IGF-1）及自身合成的钙视网膜结合蛋白（calretinin）等因子的调节。

关键词: 间质细胞, 雄激素类, 间质干细胞, 细胞增殖

Abstract: Testicular Leydig cells are main tissular cells which produce and secret androgen. The fetal Leydig cells are differentiated from the interstitial precursor cells, and postnatal Leydig cells from mesenchymal stem cells. Adolescent Leydig cells are differentiated and proliferated from the pleuripotent interstitial precursor cells, at three discontinuous developmental stages of precursor Leydig cells, immature Leydig cells and mature Leydig cells. Differentiation and development of Leydig cells in fetal stage and postnatal stage are regulated by many factors. Developmental regulators of fetal Leydig cells include the sexual determination gene Y, neurocyte adhesion molecules, transforming growth factor（TGF） and anti-Müllerian hormorne（AMH）. Proliferation and maturation, as well as differentiation, of Leydig cells after birth are regulated by endocrine, autocrine and paracrine mechanisms, such as luteinizing hormone（LH）, intratesticular androgen, estrogen, insulin-like growth factor 1（IGF-1）, calretinin and many other local cytokines.

Key words: Leydig cells, Androgens, Mesenchymal stem cells, Cell proliferation