国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (3): 241-244.

• 综述 • 上一篇    下一篇

抗苗勒管激素在女性生育力评估的临床应用

刘振兴，李红   

  1. 210029 南京医科大学（刘振兴）；南京医科大学附属苏州医院（李红）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-05-15 发布日期:2016-05-15
  • 通讯作者: 李红

The Clinical Application of Anti-Müllerian Hormone in Female Reproduction

LIU Zhen-xing，LI Hong   

  1. Nanjing Medical University，Nanjing 210029，China（LIU Zhen-xing）; Suzhou Hospital Affiliated to Nanjing Medical University，Suzhou 215002，Jiangsu Province，China（LI Hong）
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-05-15 Online:2016-05-15
  • Contact: LI Hong

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摘要： 卵子的数量和质量随年龄的增加而下降，在同龄女性中生育力的差异也很大。目前已发现多种方法预测卵巢刺激后的反应性和生殖潜能。抗苗勒管激素（AMH）是一种由小的生长卵泡内的颗粒细胞分泌的糖蛋白，可以间接反映始基卵泡池内的卵泡数量，进而反映卵巢的储备。AMH已经被用于预测体外受精（IVF）周期中卵巢刺激的反应性，预测绝经年龄，评估医源性损伤后的卵巢储备，替代窦卵泡计数（AFC）用于诊断多囊卵巢综合征（PCOS）等。

关键词: 抗苗勒管激素, 生殖技术, 辅助, 卵巢功能早衰, 卵巢肿瘤, 多囊卵巢综合征

Abstract: The number and quality of oocyte decline with age. However, the fertility varies significantly even among women of the same age. Many measures have been developed to predict the response to ovarian stimulation and the reproductive potential. Anti-Müllerian hormone (AMH), a glycoprotein secreted by the granulosa cells of small growing follicles, can indirectly reflect the number of follicles in the primordial follicle pool and thus reflect the ovarian reserve. AMH as a practical indicator has been used to predict the ovarian response in IVF cycles, to predict the age of menopause, and to assess the ovarian reserve after iatrogenic injury as well. It has also been proposed as a surrogate for antral follicle count (AFC) in the diagnosis of polycystic ovary syndrome (PCOS).

Key words: Anti-Mullerian hormone, Reproductive techniques, assisted, Ovarian failure, premature, Ovarian neoplasms, Polycystic ovary syndrome