国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (5): 423-428.

• 综述 • 上一篇    下一篇

转化生长因子β超家族在多囊卵巢综合征中的表达和作用特点

何婧妍，方兰兰，孙莹璞   

  1. 450052 郑州大学第一附属医院生殖中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-10-25 发布日期:2016-10-25

Roles of TGF-β Superfamily in Pathophysiological Mechanism of Polycystic Ovary Syndrome

HE Jing-yan, FANG Lan-lan, SUN Ying-pu   

  1. Reproductive Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-10-25 Online:2016-10-25

PDF (PC)

8007

摘要： 多囊卵巢综合征（polycystic ovary syndrome，PCOS）是生育期女性常见的一种以排卵障碍、卵巢多囊性改变、高雄激素血症、胰岛素抵抗等为主要表现的内分泌疾病，具有较高的糖尿病、心血管疾病和子宫内膜癌的发生风险。近年的研究表明，转化生长因子β（TGF-β）超家族在PCOS排卵障碍、高雄激素血症、胰岛素抵抗等多种病理过程中都发挥着重要的调控作用，此外，TGF-β超家族与PCOS的远期并发症（如心血管疾病、子宫内膜癌等）也有一定相关性。阐述TGF-β超家族中研究较为深入的部分重要成员在调控卵巢功能中的作用，并重点综述其在PCOS中的表达和作用特点。

关键词: 转化生长因子β, 多囊卵巢综合征, 无排卵, 雄激素增多症, 胰岛素抗药性

Abstract: Polycystic ovary syndrome (PCOS), a common endocrine disorder in women of reproductive age, is characterized by anovulation, hyperandrogenism and insulin resistance. Moreover, PCOS have the increased risk of diabetes, cardiovascular diseases, and endometrial cancer. Recent studies indicated that TGF-β surperfamily plays an important role in various pathological processes of PCOS, such as anovulation, hyperandrogenism ，insulin resistance and so on. In addition, it has a correlation with the long-term complications of PCOS, such as cardiovascular disease, endometrial cancer and so on. This review will demonstrate the role of important members of TGF-β superfamily in the regulation of ovarian function, especially the expression and role in pathophysiological mechanism of PCOS.

Key words: Transforming growth factor beta, Polycystic ovary syndrome, Anovulation, Hyperandrogenism, Insulin resistance