国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (6): 483-485.

• 综述 • 上一篇    下一篇

发育源性成人疾病

邓冉冉，李洁，李增彦   

  1. 300052 天津医科大学总医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-12-25 发布日期:2016-12-25

Developmental Origins of Adult Diseases

DENG Ran-ran, LI Jie, LI Zeng-yan   

  1. Department of Obstetrics and Gynecology, Tianjin Medical University General Hospital, Tianjin 300052, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-12-25 Online:2016-12-25

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摘要： 发育源性成人疾病是在“成人疾病的胎儿起源”这一假说的基础上发展而来，表明胎儿宫内环境、新生儿、儿童期乃至人类生长发育的各个阶段所处的环境都会对成人疾病产生影响，其生物学基础有发育的可塑性及“追赶生长”、基因机制、激素的编程等。发育源性成人疾病包括心血管疾病、2型糖尿病、多囊卵巢综合征、炎症性和免疫性疾病等非感染性慢性疾病。本文就发育源性成人疾病的假说、生物学基础、可能的疾病类型及其发育源性的相关研究进行阐述。

关键词: 发育源性成人疾病, 婴儿, 出生时低体重, 心血管疾病, 糖尿病, 2型, 多囊卵巢综合征, 炎症

Abstract: "Developmental origins of adult disease", based on the concept of ＂fetal origins of adult disease", was used to demonstrate the effect of the fetus intrauterine environment and the developmental environment of newborn, childhood and adult on those adult diseases. The potential biological mechanism included the developmental plasticity, compensatory growth, genetic and epigenetics, hormonal adaptations, etc. Those non-infectious chronic diseases, such as cardiovascular disease, type 2 diabetes, PCOS, inflammatory and autoimmune diseases, are attributed to the "developmental origins of adult disease". In this review, we discussed the hypothesis of "developmental origins of adult disease", the biological basis and potential mechanism, the disease types, and its research progress.

Key words: Development origin of adult disease, Infant, low birth weight, Cardiovascular diseases, Diabetes mellitus, type 2, Polycystic ovary syndrome, Inflammation