关键词: 【关键词】 流产, 脂肪细胞因子, 脂联素, 瘦素, 肿瘤坏死因子α, 内脂素, 白细胞介素

Abstract: 【Abstract】 Adipocytokines such as adiponectin, leptin, tumor necrosis factor-α (TNF-α), visfatin, and interleukins (ILs) can affect embryo implantation, intrauterine environment, maternal fetal immune balance, and then cause early spontaneous abortion. Endometrial receptivity is affected by adiponectin through actions of both paracrine and autocrine. Leptin can regulate the growth and development of zygote through the regulation of gonadotropins secretion by central nervous system. TNF-α can promote the development of embryo by regulating the proliferation and differentiation of trophoblasts. The proinflammatory effect of visfatin is beneficial to the maintenance of pregnancy. Imbalances among ILs lead to the abnormal immune status at the maternal-fetal interface. This paper summarizes advances on roles of adiponectin, leptin, TNF-α, visfatin, and ILs in the pathogenesis of early spontaneous abortion.

Key words: 【Keywords】 Abortion, Adipocytokine, Adiponectin, Leptin, Tumor necrosis factor-alpha, Visfatin, Interleukin