白细胞介素33在妊娠相关疾病中的作用

doi:10.12280/gjszjk.20210110

摘要/Abstract

摘要：

白细胞介素33（IL-33）属于IL-1β家族,是新发现的核定位因子,具有抗炎、促炎双重效应。IL-33可通过参与调节母胎免疫耐受过程以维持正常妊娠,同时,IL-33在多种妊娠相关疾病中发挥重要作用,如妊娠早期IL-33的表达异常或功能障碍可导致流产;胎盘中IL-33降低致使滋养细胞功能障碍,与子痫前期患者胎盘功能不良有关;妊娠中晚期蜕膜中IL-33表达降低或功能障碍在早产的发生发展中发挥重要作用;IL-33可触发多种细胞的钙通道增加细胞内的钙离子水平,且已发现钙离子在子宫平滑肌收缩中发挥重要作用,但是关于IL-33在子宫平滑肌的研究尚待深入。而早产的发生最终都伴随着子宫平滑肌收缩, 故探讨IL-33在妊娠相关疾病以及平滑肌细胞收缩中的作用,有助于进一步研究早产的发生发展机制,从而为早产的诊治提供新思路。

关键词: 白细胞介素33, 肌细胞, 钙通道, 流产,习惯性, 先兆子痫

Abstract:

Interleukin 33 (IL-33) belongs to the IL-1β family and is a newly discovered nuclear localization factor with dual anti-inflammatory and pro-inflammatory effects. Studies have shown that IL-33 can maintain normal pregnancy by participating in the process of regulating maternal-fetal immune tolerance. At the same time, IL-33 plays an important role in a variety of pregnancy-related diseases. Abnormal expression or dysfunction of IL-33 in early pregnancy can lead to miscarriage. The decrease of IL-33 in the placenta leads to trophoblast dysfunction, which is related to poor placental function of preeclampsia patients. Decreased expression of IL-33 or dysfunction in the decidua in the middle and late stages of pregnancy plays an important role in the occurrence and development of preterm birth. Although IL-33 can trigger calcium flux in a variety of cells and increase the level of calcium ions in cells, and calcium ions play an important role in uterine smooth muscle contraction, the research on IL-33 in uterine smooth muscle has not been in-depth. The occurrence of preterm birth is ultimately accompanied by uterine smooth muscle contraction, therefore, study on the role of IL-33 in pregnancy-related diseases and the contraction of smooth muscle cells will help to further study the mechanism of occurrence and development of preterm birth, thereby providing new ideas for the diagnosis and treatment of preterm birth.

Key words: Interleukin-33, Muscle cells, Calcium channels, Abortion, habitual, Pre-eclampsia

曹小宛, 陈黎, 宋珍珍, 张国英. 白细胞介素33在妊娠相关疾病中的作用[J]. 国际生殖健康/计划生育, 2021, 40(5): 427-430.

CAO Xiao-wan, CHEN Li, SONG Zhen-zhen, ZHANG Guo-ying. Advances in the Role of IL-33 in Pregnancy-Related Diseases[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(5): 427-430.

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