国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2018, Vol. 37 ›› Issue (4): 269-272.

• 论著 •    下一篇

多囊卵巢综合征患者焦虑、抑郁状态及其相关影响因素研究

张莉莉，马将，张成，郑冬雪，刘新敏，周雪忠   

  1. 100053  北京，中国中医科学院广安门医院（张莉莉，马将，张成，郑冬雪，刘新敏）；北京交通大学计算机与信息技术学院（周雪忠）
  • 收稿日期:2018-03-02 修回日期:2018-04-22 出版日期:2018-07-15 发布日期:2018-07-15
  • 通讯作者: 刘新敏，E-mail：beijingliuxm@163.com E-mail:beijingliuxm@163.com
  • 基金资助:
    国家自然科学基金面上项目（81674011）

Anxiety and Depression in Patients with Polycystic Ovary Syndrome and Relevant Factors

ZHANG Li-li，MA Jiang，ZHANG Cheng，ZHENG Dong-xue，LIU Xin-min，ZHOU Xue-zhong   

  1. Guanganmen Hospital of China Academy of Chinese Medical Sciences，Beijing 100053，China（ZHANG Li-li，MA Jiang，ZHANG Cheng，ZHENG Dong-xue，LIU Xin-min）；College of Computer and Information Technology，Beijing Jiaotong University，Beijing 100044，China（ZHOU Xue-zhong）
  • Received:2018-03-02 Revised:2018-04-22 Published:2018-07-15 Online:2018-07-15
  • Contact: LIU Xin-min，E-mail：beijingliuxm@163.com E-mail:beijingliuxm@163.com

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摘要： 目的：探讨多囊卵巢综合征（polycystic ovary syndrome，PCOS）患者的焦虑、抑郁状态及其相关影响因素以及焦虑、抑郁状态与脑电功能变化的关系。方法：选取2016年12月—2017年3月就诊于中国中医科学院广安门医院妇科门诊的58例PCOS患者（PCOS组），35例年龄匹配的健康女性（对照组），填写调查问卷、焦虑自评量表（SAS）、抑郁自评量表（SDS）、生活事件量表（LES）和社会支持量表（SSRS）；已婚者填写双方性调节量表（DRS）。所有参加者均由心身医学科专业医生行脑电地形图检查（BEAM）。结果：PCOS组的SAS、SDS得分均高于对照组（均P=0.000）。PCOS组LES得分高于对照组（Z=-2.217，P=0.027），具体体现在，PCOS组负性LES和其中家庭有关问题的得分高于对照组（均P＜0.05），而正性LES及负性LES中的工作学习问题和社交或其他问题得分，2组比较差异无统计学意义（均P＞0.05）。2组SSRS得分比较差异无统计学意义（P＞0.05）。2组已婚者分别为38例、7例，DRS得分比较差异无统计学意义（P＞0.05）。PCOS组BEAM结果异常者比对照组增多（Z=－5.447，P＜0.01），PCOS组各脑区慢波δ、θ功率值较对照组升高（均P＜0.05）。PCOS组患者BEAM得分与SAS、SDS得分呈正相关（rs=0.447，P=0.000；rs=0.318，P=0.002），SAS得分与SDS得分呈正相关（r=0.706，P=0.000）。结论：PCOS患者存在明显的焦虑、抑郁情绪，二者互相影响，这些负性情绪与来自家庭方面的负性生活事件有关。负性情绪的长期存在可能影响患者的脑电功能。

关键词: 多囊卵巢综合征, 表现焦虑量表, 抑郁, 脑图

Abstract: Objective：To investigate the anxiety and depression in patients with polycystic ovary syndrome (PCOS) and the related factors, and to analyze the relationship between the anxiety and depression and the change of electroencephalogram function. Methods：A total of 58 patients with PCOS who were treated at gynecological outpatient department of Guang′anmen Hospital of China Academy of Chinese Medical Sciences from December 2016 to March 2017 were enrolled as the PCOS group, and 35 age-matched normal women as the control group. The questionnaire, self rating anxiety scale (SAS), self rating depression scale (SDS), life events scale (LES) and social support scale (SSRS) for all objects, as well as the dyadic regulation scale (DRS) for those married objects (n=38 and 7, respectively), were used in this study. The brain electrical activity mapping (BEAM) was used to evaluate the electroencephalogram function. Results：The scores of SAS and SDS in the PCOS group were significantly increased than that in the control group (P=0.000). Compared with the control group, the PCOS group had significantly higher score of LES (Z=－2.217, P=0.027), specifically the subscores of life negative events and family-related questions (all P＜0.05). However, there were no significant differences between the two groups in the scores of positive events and work-learning problems and social or other problems in negative life events (all P＞0.05), and also no difference in the score of SSRS (P＞0.05). There were no significant difference in the score of DRS in those married objects between the two groups (P＞0.05). The rate of abnormal BEAM were significantl increased in the PCOS group than in the control group (Z=－5.447, P＜0.01). The PCOS group had the increased brand power of slow δ and θ waves (P＜0.05). There were a significant positive correlation between the BEAM and SAS and SDS (rs=0.447, P=0.000; rs=0.318, P=0.002) and a positive correlation between SAS and SDS (r=0.706, P=0.000) in the PCOS group. Conclusions：PCOS patients had obvious anxiety and depression, and the interplay between anxiety and depression. These negative emotions were related to the negative life events coming from their family. The long-term of negative emotions may affect their electroencephalogram function.

Key words: Polycystic ovary syndrome, Manifest anxiety scale, Depression, Brain mapping