关键词: 卵巢肿瘤, 长链非编码RNA, 微RNAs, 竞争性内源RNA

Abstract: Most parts of the human genome are non-coding regions which produce non-coding RNA (ncRNA). Although ncRNAs cannot be translated into protein, it can affect human physiological and pathological processes through direct and indirect regulation of mRNA. Long non-coding RNA (lncRNA) is important branch of ncRNAs. LncRNA is involved in cancer cell proliferation, migration, invasion, apoptosis and drug resistance, etc. Therefore, lncRNA could be used as a marker of early diagnosis and prognosis, and therapeutic target of tumors. The hypothesis of the competitive endogenous RNAs (ceRNA) network has led to a further understanding of the mechanism of tumorigenesis. LncRNA is indispensable in the formation of the ceRNA network. In recent years, there have been more and more research on the lncRNA in ovarian cancer (OC). In this paper, we review the advance of lncRNA as a member of ceRNA network in the pathogenesis of OC.

Key words: Ovarian neoplasms, Long non-coding RNA, MicroRNAs, Competitive endogenous RNAs