国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2019, Vol. 38 ›› Issue (4): 318-322.

• 综述 • 上一篇    下一篇

锌转运体对男性（雄性）生殖作用的研究进展

施磊，蒋晨依，吴望舒，朱欣烨，余承瑄，刘悦，丁之德   

  1. 200025 上海交通大学医学院临床医学系2017级临床八年制（施磊，蒋晨依，吴望舒，朱欣烨），临床医学系2017级临床五年制（余承瑄），组织胚胎学与遗传发育学系（刘悦，丁之德）
  • 收稿日期:2019-05-06 修回日期:2019-05-24 出版日期:2019-07-15 发布日期:2019-07-15
  • 通讯作者: 刘悦，E-mail：liuyue@shsmu.edu.cn；丁之德，E-mail：zding@shsmu.edu.cn E-mail:zding@shsmu.edu.cn
  • 基金资助:
    上海交通大学基础医学院RBL项目（2019001）

Research Advances on the Role of Zinc Transporter in Male Reproduction

SHI Lei，JIANG Chen-yi，WU Wang-shu，ZHU Xin-ye，YU Cheng-xuan，LIU Yue，DING Zhi-de   

  1. Department of Clinical Medicine，Grade 2017，8 years program（SHI Lei，JIANG Chen-yi，WU Wang-shu，ZHU Xin-ye），Department of Clinical Medicine，Grade 2017，5 years program（YU Cheng-xuan），Department of Histology，Embryology，Genetics and Developmental Biology（LIU Yue，DING Zhi-de），School of Medicine，Shanghai Jiao Tong University，Shanghai 200025，China
  • Received:2019-05-06 Revised:2019-05-24 Published:2019-07-15 Online:2019-07-15
  • Contact: LIU Yue，E-mail：liuyue@shsmu.edu.cn；DING Zhi-de，E-mail：zding@shsmu.edu.cn E-mail:zding@shsmu.edu.cn

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摘要： 锌对精子的发育成熟非常关键，而介导锌转运的锌转运体主要来自于锌转运蛋白（Zinc transporter，ZnT）和锌铁调控转运蛋白（Zrt-，Irt-like protein，ZIP）两大家族。在睾丸中，不同的锌转运体依次表达于生精细胞质膜上，参与精子发生和精子形成过程；此外，血睾屏障的维持以及睾酮的生物合成亦需要相应的锌转运体参与。附睾上皮组织高表达ZnT，附睾内精子表面有ZIP1、ZIP5、ZIP6和ZIP8，其有助于精子对锌的吸收且参与精子成熟过程。前列腺腺上皮细胞通过ZIP1吸收血液中的锌，以维持前列腺组织高锌水平；另一方面，该上皮也可通过ZIP2、ZIP3及ZIP4重吸收前列腺液中的锌，确保精浆中重要的抗氧化剂柠檬酸盐的正常分泌。综述锌及其转运体在男性（雄性）生殖中的作用对于了解其生殖过程的发生及男性不育的病理机制均有十分重要的意义。

关键词: 锌, 生殖器, 男（雄）性, 精子, 锌转运蛋白, 锌铁调控转运蛋白

Abstract: Zinc is a critical factor of sperm maturation. Zinc transfer is mediated by zinc transporters that are composed of two protein families, Zinc transporter (ZnT) and Zrt-, Irt-like protein (ZIP). In testis, Zinc transporters expressed on the membrane of germ cells participate in spermatogenesis and spermiogenesis. In addition, Zinc transporters are also involved in maintaining blood-testis barrier and testosterone biosynthesis. In epididymis, ZnTs expressed highly in epithelial tissues, and ZIP1, ZIP5, ZIP6 and ZIP8 distributed widely on the epididymal sperm surface, are contributed to the zinc absorption by sperm and sperm maturation. In prostatic epithelial cells, zinc is absorbed from blood via ZIP1 in order to maintain a high zinc level in prostate. On the other hand, zinc is reabsorbed from prostatic fluid via ZIP2, ZIP3 and ZIP4 to ensure the normal secretion of citrate, an important anti-oxidant. The role of zinc and zinc transporters in the male reproductive system was reviewed in this paper, which is helpful for us to understand male reproduction and male infertility.

Key words: Zinc, Genitalia, male, Spermatozoa, Zinc transporter, Zrt-, Irt-like protein