国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2019, Vol. 38 ›› Issue (6): 471-477.

• 论著 • 上一篇    下一篇

卵泡刺激素与绝经女性代谢综合征相关性的Meta分析

麻婷，孙小燕，于潇，张学红   

  1. 730000 兰州大学第一医院生殖医学专科医院，甘肃省生殖医学与胚胎重点实验室
  • 收稿日期:2019-06-17 修回日期:2019-08-03 出版日期:2019-11-15 发布日期:2019-11-15
  • 通讯作者: 张学红，E-mail：zhangxueh@lzu.edu.cn E-mail:zhangxueh@lzu.edu.cn;ldszzx@yahoo.com.cn
  • 基金资助:
     

Correlation between FSH and Metabolic Syndrome in Postmenopausal Women: A Meta-Analysis

MA Ting，SUN Xiao-yan，YU Xiao，ZHANG Xue-hong   

  1. Reproductive Medicine Special Hospital of the First Hospital of Lanzhou University，Key Laboratory for Reproductive Medicine and Embryo of Gansu Province，Lanzhou 730000，China
  • Received:2019-06-17 Revised:2019-08-03 Published:2019-11-15 Online:2019-11-15
  • Contact: ZHANG Xue-hong，E-mail：zhangxueh@lzu.edu.cn E-mail:zhangxueh@lzu.edu.cn;ldszzx@yahoo.com.cn
  • Supported by:
     

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摘要： 目的：探讨绝经后女性代谢综合征（MS）和血清卵泡刺激素（FSH）水平的相关性。方法：检索PubMed、Web of Science、CNKI和VIP数据库，搜集有关绝经女性FSH水平和MS关系的观察性研究，检索时间均为建库至2019年3月31日，检索语种为中英文。采用RevMan 5.3软件对纳入的研究进行Meta分析。结果：共有6个病例-对照研究及2个横断面研究纳入Meta分析，包括494例MS绝经女性和603例非MS绝经女性。Meta分析结果显示，MS绝经女性FSH水平和非MS绝经女性比较，差异无统计学意义（SMD=-0.22，95%CI：-0.71～0.26，P=0.37）。亚组分析显示，酶联免疫法检测的MS绝经女性FSH水平与非MS绝经女性比较，差异无统计学意义（SMD=-0.29，95%CI：-0.93～0.35，P=0.38）；化学发光免疫法（SMD=-0.72，95%CI：-1.03～-0.41，P＜0.000 01）和放射免疫法（SMD=-0.38，95%CI：-0.65～-0.11，P=0.006）检测的MS绝经女性FSH水平均低于非MS绝经女性，差异均有统计学意义；绝经早期和中期MS女性较非MS女性FSH水平更低（SMD=-0.63，95%CI：-0.96～-0.31， P=0.000 1；SMD=-0.70，95%CI：-1.08～-0.32，P=0.000 3）。经敏感性分析剔除异质性较大的研究后合并显示，MS绝经女性FSH水平低于非MS绝经女性，差异有统计学意义（SMD=-0.44，95%CI：-0.77～-0.11，P=0.009）。结论：低水平的FSH可能是绝经女性MS的危险因素。

关键词: 代谢综合征, 代谢疾病, 绝经期, 卵泡刺激素, Meta分析

Abstract: Objective：To investigate the correlation between metabolic syndrome (MS) and serum follicle-stimulating hormone (FSH) level in postmenopausal women. Methods：PubMed, Web of Science, CNKI and VIP databases were searched to collect observational studies on the relationship between FSH level and MS in postmenopausal women. The retrieval time was from the establishment of the database to March 31, 2019, and the languages were Chinese and English. RevMan 5.3 software was used for Meta analysis. Results：A total of 6 case-control studies and 2 cross-sectional studies were included in the meta-analysis, including 494 cases of post-menopausal women with MS and 603 cases of post-menopausal women without MS. There was no significant difference in FSH level between postmenopausal women with MS and without MS. The subgroup analysis also showed that there was no significant difference in the FSH level detected by enzyme-linked immunoassay between above two groups (SMD=-0.29, 95%CI: -0.93～0.35, P=0.38). However, the FSH level detected by chemiluminescence (SMD=-0.72, 95%CI: -1.03～-0.41, P＜0.000 01), or by radioimmunoassay (SMD=-0.38, 95%CI: -0.65～-0.11, P=0.006), in MS postmenopausal women was significantly lower than that in non-MS post-menopausal women. In addition, FSH levels in early and middle menopausal MS women were lower than those in non-MS menopausal women. After sensitivity analysis, FSH level of post-menopausal MS women was significantly lower than that of post-menopausal non-MS women (SMD=-0.44, 95%CI: -0.77～-0.11, P=0.009). Conclusions：The lowered level of FSH may be a risk factor of MS in postmenopausal women.

Key words: Metabolic syndrome, Metabolic diseases；Menopause, Follicle stimulating hormone, Meta-analysis

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