国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2020, Vol. 39 ›› Issue (2): 117-120.

• 论著 • 上一篇    下一篇

正常体质量指数的多囊卵巢综合征与胰岛素抵抗相关的危险因素分析

于婧璐，侯丽辉，孙淼，王颖   

  1. 150040 哈尔滨，黑龙江中医药大学（于婧璐）；黑龙江中医药大学附属第一医院妇科门诊（侯丽辉，王颖），妇科（孙淼）
  • 收稿日期:2019-12-09 修回日期:2020-01-13 出版日期:2020-03-15 发布日期:2020-03-15
  • 通讯作者: 侯丽辉，E-mail：houlihui@sina.com E-mail:404443615@qq.com
  • 基金资助:
    国家自然科学基金（81804138）

Logistic Regression Analysis of Risk Factors Related to Insulin Resistance in Patients with Polycystic Ovary Syndrome and Normal Body Mass Index

YU Jing-lu，HOU Li-hui，SUN Miao，WANG Ying   

  1. Heilongjiang University of Chinese Medicine，Harbin 150040，China（YU Jing-lu）；Cynaecological Clinic（HOU Li-hui，WANG Ying），Department of Gynecology（SUN Miao），The First Affiliated Hospital of Heilongjiang University of Chinese Medicine，Harbin 150040，China
  • Received:2019-12-09 Revised:2020-01-13 Published:2020-03-15 Online:2020-03-15
  • Contact: HOU Li-hui，E-mail：houlihui@sina.com E-mail:404443615@qq.com
  • Supported by:
     

PDF (PC)

8960

摘要： 目的：研究正常体质量指数（BMI）的多囊卵巢综合征（PCOS）患者诱发胰岛素抵抗（IR）的相关临床危险因素。方法：选取2018年3月—2019年5月就诊于黑龙江中医药大学附属第一医院妇科门诊的PCOS患者203例，根据稳态模型胰岛素抵抗指数（HOMA-IR）将患者分为2组，HOMA-IR≥2.69为PCOS伴IR组（IR组，50例）；HOMA-IR＜2.69为PCOS不伴IR组（对照组，153例），比较2组临床特征、性激素水平以及糖脂代谢水平的差异性，分析临床特征和性激素、脂代谢水平与HOMA-IR间的相关性，应用多因素Logistic回归分析与IR相关的临床影响因素。结果：IR组腰围（WC）、臀围（HC）、腰臀比（WHR）、雄烯二酮（AND）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、尿酸（UA）水平高于对照组，卵泡刺激素（FSH）、性激素结合球蛋白（SHBG）、高密度脂蛋白胆固醇（HDL-C）水平低于对照组（P＜0.05）。WC、HC、TG与HOMA-IR呈低度正相关（P＜0.05），SHBG、HDL-C与HOMA-IR呈低度负相关（P＜0.05），WHR、AND、LDL-C呈弱正相关（P＜0.05）。WC是正常BMI的PCOS患者发生IR的危险因素，HDL-C是正常BMI的PCOS患者发生IR的保护因素（P＜0.05）。结论：WC可能诱发正常BMI的PCOS并发IR，HDL-C可能预防正常BMI的PCOS患者出现IR。

关键词: 多囊卵巢综合征；, 胰岛抵抗；, 体重指数；, Logistic模型；, 性腺甾类激素

Abstract: Objective: To study the clinical risk factors of insulin resistance (IR) in patients with polycystic ovary syndrome (PCOS) and normal body mass index (BMI). Methods：A total of 203 PCOS patients with normal BMI from our hospital, from March 2018 to May 2019, were included in this study. According to the homeostasis model assessment-insulin resistance index (HOMA-IR), the patients were divided into two groups: the observation group (PCOS with normal BMI and HOMA-IR≥2.69, n=50); the control group (PCOS with normal BMI and HOMA-IR＜2.69, n=153 cases). The clinical characteristics, sexual hormone levels and glycolipid metabolism of the two groups were compared. The correlation between clinical characteristics, sex hormone levels, lipid metabolism and HOMA-IR was analyzed. The clinical risk factors related to IR were analyzed by multivariate Logistic regression. Results：The levels of WC, HC, WHR, TG, LDL-C, and UA in the observation group were significantly higher than those in the control group, and the levels of FSH, SHBG and HDL-C were significantly lower (all P＜0.05). The levels of WC, HC and TG were positively correlated with HOMA-IR (all P＜0.05), and the levels of WHR and LDL-C were weakly positively correlated (both P＜0.05), while the levels of SHBG and HDL-C were negatively correlated with HOMA-IR (both P＜0.05). WC is the risk factor of inducing IR in PCOS patients with normal BMI, and HDL-C is the protective factor of preventing IR in PCOS patients with normal BMI (both P＜0.05). Conclusions：WC as a risk factor can induce IR in those PCOS patients with normal BMI, and HDL-C acts as a protective factor.

Key words: Polycystic ovary syndrome；, Insulin resistance；, Body mass index；, Logistic models；, Gonadal steroid hormones

中图分类号: