国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2020, Vol. 39 ›› Issue (5): 365-369.

• 论著 • 上一篇    下一篇

宫腔内灌注自体培养外周血单个核细胞对反复种植失败患者妊娠结局影响的Meta分析

谭艳，龙文香，周春慧，李娟娟，杨章莉   

  1. 412000   湖南省株洲市妇幼保健院生殖科
  • 收稿日期:2020-03-11 修回日期:2020-05-18 出版日期:2020-09-15 发布日期:2020-09-11
  • 通讯作者: 杨章莉，E-mail：690072526@qq.com E-mail:1473067003@qq.com
  • 基金资助:
    湖南省自然科学基金（2018JJ4090）

Effect of Intrauterine Perfusion of Autologous Peripheral Blood Mononuclear Cells on Pregnancy Outcomes in Patients with Repeated Implantation Failure：A Meta-Analysis

TAN Yan，LONG Wen-xiang，ZHOU Chun-hui，LI Juan-juan，YANG Zhang-li   

  1. Department of Reproductive，Women and Children Healthcare Hospital of Zhuzhou，Zhuzhou 412000，Hunan Province，China
  • Received:2020-03-11 Revised:2020-05-18 Published:2020-09-15 Online:2020-09-11
  • Contact: YANG Zhang-li，E-mail：690072526@qq.com E-mail:1473067003@qq.com

PDF (PC)

8970

摘要： 目的：评价宫腔内灌注自体培养外周血单个核细胞（PBMC）对反复种植失败（RIF）患者妊娠结局的影响。方法：电子检索建库至2020年1月PubMed、Medline（via.OvidSP）、Embase、The Cochrane Library、中国知网（CNKI）、万方数据库（WanFang Data）、维普信息资源系统（VIP）等各大数据库所有相关文献，采用RevMan 5.3软件进行Meta分析。结果：纳入12篇文献，5篇随机对照研究和7篇队列研究，共1 170例RIF患者（PBMC组635例，对照组535例）。PBMC组患者的胚胎种植率（RR=2.24，95%CI：1.42～3.54，P＜0.01）、临床妊娠率（RR=2.91，95%CI：2.21～3.87，P＜0.001）和活产率（RR=2.25，95%CI：1.62～3.12，P＜0.001）均高于对照组，但2组流产率比较差异无统计学意义（RR=0.48，95%CI：0.20～1.17，P＞0.05）。结论：宫腔内灌注自体培养PBMC能提高RIF患者的胚胎种植率、临床妊娠率和活产率，是治疗RIF的有效措施。

关键词: 单核细胞；, 胚胎移植；, 体外受精；, 生殖技术, 辅助；, 反复种植失败；, 外周血单个核细胞

Abstract: Objective: To evaluate the effect of intrauterine autologous peripheral blood mononuclear cell (PBMC) perfusion on the pregnancy outcomes in patients with repeated implantation failure (RIF). Methods：All of the relevant literatures published in PubMed, Medline (via.OvidSP), Embase, the Cochrane Library, CNKI, WanFang Data, VIP and other major databases were retrieved electronically from their establishment to January 2020. Meta analysis was performed using RevMan 5.3 software. Results：There were 12 articles, including 5 randomized controlled trials and 7 cohort studies, were  enrolled in this Meta analysis, with a total of 1 170 RIF patients (635 received PBMC perfusion and other 535  for controls). The embryo implantation rate (RR=2.24, 95%CI: 1.42-3.54, P＜0.01), clinical pregnancy rate (RR=2.91, 95%CI: 2.21-3.87, P＜0.001) and the live birth rate (RR=2.25, 95%CI: 1.62-3.12, P＜0.001) in patients received PBMC perfusion were higher than those in the control group. However, there was no significant difference in the abortion rate between the two groups (RR=0.48, 95%CI: 0.20-1.17, P＞0.05). Conclusions：Intrauterine infusion of PBMC can improve the embryo implantation rate, clinical pregnancy rate and live birth rate of RIF patients, which is an effective measure for the treatment of RIF.

Key words: Monocytes；, Embryo transfer；, Fertilization in vitro；, Reproductive techniques, assisted；, Recurrent implantation failure；, Peripheral blood mononuclear cells