内分泌干扰物对女性生育力和辅助生殖技术结局的影响

doi:10.12280/gjszjk.20230082

摘要/Abstract

摘要：

内分泌干扰物（endocrine disrupting chemicals，EDC）是外源性化合物，能干扰激素的作用并影响内分泌途径，影响女性生殖系统发育和卵巢功能，且与不孕症的发生相关。目前研究方向多集中在EDC的暴露及其与不同内分泌轴上疾病的相关性方面，研究表明EDC所致的卵巢功能减退、卵泡发育异常、子宫内膜容受性降低、胚胎质量下降会影响女性的生育能力，并进一步影响不孕女性的辅助生殖临床结局。此外，在动物研究中积累的证据为EDC的效应机制提供了重要的见解。根据目前的研究数据总结分析一些最常见的EDC，包括农药、双酚A和邻苯二甲酸盐对女性生育能力和辅助生殖技术的影响。

关键词: 内分泌干扰物, 农药, 二乙基己基邻苯二甲酸, 生育力, 生殖技术，辅助

Abstract:

Endocrine disrupting chemicals(EDC) are exogenous compounds, which can interfere with the hormones action and endocrine pathways, affect the development of female reproductive system and ovarian function, and therefore EDCs are associated with female infertility. Current research mainly focus on EDC exposure and its correlation with the different diseases of the endocrine axes. Studies have shown that EDCs affect female fertility by causing ovarian dysfunction, follicular development abnormality, endometrial receptivity reduction, and embryo quality decline, as well as the lowed clinical outcome of assisted reproduction in infertile women. Accumulating evidence in animal studies has provided important insights into the mechanism of EDC effects. This review summarizes some of the most common EDCs including pesticides, bisphenol A and phthalates, and the effects of EDCs on female fertility and clinical outcomes of assisted reproductive technology.

Key words: Endocrine disruptors, Pesticides, Diethylhexyl phthalate, Fertility, Reproductive techniques, assisted

邓美香, 石一柱, 冯兰青. 内分泌干扰物对女性生育力和辅助生殖技术结局的影响[J]. 国际生殖健康/计划生育杂志, 2023, 42(4): 304-309.

DENG Mei-xiang, SHI Yi-zhu, FENG Lan-qing. The Effects of Endocrine Disrupting Chemicals on Female Fertility and Outcomes of Assisted Reproductive Technolog[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(4): 304-309.

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