中药活性成分调控PI3K/Akt信号通路治疗卵巢癌的作用机制

doi:10.12280/gjszjk.20250247

摘要/Abstract

摘要：

卵巢癌（ovarian cancer，OC）是女性常见的恶性肿瘤之一，其起病隐匿，大多数患者确诊时已处于晚期，故临床治疗效果较差。目前OC的治疗常以化疗和手术为主，但化疗耐药及不良反应仍是临床难题。研究表明，OC的发生发展与多条信号通路的异常表达有关，其中磷脂酰肌醇3激酶（phosphoinositide 3-kinase，PI3K）/蛋白激酶B（protein kinase B，Akt）信号通路的异常激活与OC的发生发展密切相关。研究发现，中药活性成分可调控PI3K/Akt信号通路，抑制OC细胞增殖、侵袭与迁移、血管生成，并可促进OC细胞凋亡，改善OC细胞化疗敏感性。综述PI3K/Akt信号通路在OC中的作用，以及中药活性成分调控PI3K/Akt信号通路作用机制的研究进展，以期为中医药在治疗或辅助治疗OC的临床应用提供参考。

关键词: 卵巢肿瘤, 抗肿瘤药（中药）, 磷酸肌醇3-激酶类, 原癌基因蛋白质c-akt, 细胞增殖, 细胞运动, 细胞凋亡

Abstract:

Ovarian cancer (OC) is one of the common malignant tumors in women. Most of patients are diagnosed at the advanced stage due to its insidious onset, resulting in poor clinical treatment outcomes. Currently, the treatment of OC mainly relies on chemotherapy and surgery, but the chemotherapy resistance and adverse reactions remain the clinical challenge. Studies have shown that the abnormal expressions of multiple signaling pathways are related to the pathogenesis of OC, such as the abnormal activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. The active components of traditional Chinese medicine can regulate the PI3K/Akt signaling pathway to inhibit the proliferation, invasion, migration and angiogenesis of OC cells, to promote the apoptosis of OC cells, and to improve the chemosensitivity of OC cells. This review summarizes the role of the PI3K/Akt signaling pathway in OC and the research progress on the mechanism of the active components of traditional Chinese medicine in regulating the PI3K/Akt signaling pathway, with the aim of providing a reference for the clinical application of traditional Chinese medicine in the treatment or adjutant therapy of OC.

Key words: Ovarian neoplasms, Antineoplastic agents (TCD), Phosphatidylinositol 3-kinases, Proto-oncogene proteins c-akt, Cell proliferation, Cell movement, Apoptosis

张丽倩, 陆润国, 王宇, 石百超, 吴效科. 中药活性成分调控PI3K/Akt信号通路治疗卵巢癌的作用机制[J]. 国际生殖健康/计划生育杂志, 2025, 44(5): 434-440.

ZHANG Li-qian, LU Run-guo, WANG Yu, SHI Bai-chao, WU Xiao-ke. The Mechanism of Active Components of Traditional Chinese Medicine in Treating Ovarian Cancer by PI3K/Akt Signaling[J]. Journal of International Reproductive Health/Family Planning, 2025, 44(5): 434-440.

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