白藜芦醇在妇科恶性肿瘤中的研究进展

doi:10.12280/gjszjk.20250260

摘要/Abstract

摘要：

卵巢癌、宫颈癌及子宫内膜癌是妇科常见三大恶性肿瘤，探索更安全高效的治疗方法以提高患者的远期生存率和生活质量成为当前研究的热点。白藜芦醇（resveratrol，RES）是一种天然的多酚类化合物，存在于多种植物中。近年大量研究表明，RES对恶性肿瘤的治疗具有一定价值，其机制十分复杂，可通过抗炎、免疫调节、抑制肿瘤增殖和转移、促进细胞自噬和凋亡、抑制血管生成等发挥抗肿瘤作用。结合国内外最新研究，综述RES在三大妇科恶性肿瘤中的作用及相关机制，以期为开发RES应用于妇科恶性肿瘤临床治疗提供科学依据。

关键词: 白藜芦醇, 生殖器肿瘤, 女（雌）性, 癌, 卵巢肿瘤, 宫颈肿瘤, 子宫内膜肿瘤

Abstract:

Ovarian cancer, cervical cancer and endometrial cancer are the three common malignant tumors in gynecology, and exploring safer and more efficient treatments to improve the long-term survival rate and life quality of patients has become a hot topic in the current research. Resveratrol (RES), a natural polyphenolic compound, exists in a variety of plants. In recent years, a large number of studies have shown that RES has a certain value in the treatment of malignant tumors. The mechanism of RES anti-tumor role is very complex, including anti-inflammatory, immunomodulation, inhibition of tumor proliferation and metastasis, promotion of autophagy and apoptosis, and inhibition of angiogenesis. In this paper, we review the role and mechanism of RES in the three major gynecologic malignant tumors, in order to provide a scientific basis for the development of RES clinical application in the treatment of gynecologic malignant tumors.

Key words: Resveratrol, Genital neoplasms, female, Carcinoma, Ovarian neoplasms, Uterine cervical neoplasms, Endometrial neoplasms

谢久梅, 王宇, 陈香楠, 张丽倩, 吴效科. 白藜芦醇在妇科恶性肿瘤中的研究进展[J]. 国际生殖健康/计划生育杂志, 2025, 44(6): 524-528.

XIE Jiu-mei, WANG Yu, CHEN Xiang-nan, ZHANG Li-qian, WU Xiao-ke. Research Progress on Resveratrol in Gynecologic Malignant Tumor[J]. Journal of International Reproductive Health/Family Planning, 2025, 44(6): 524-528.

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