国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (1): 5-7.

• 论著 • 上一篇    下一篇

子宫内膜异位症未累及卵巢对卵巢储备功能的影响

张 荣;刘雨生;童先宏; 骆丽华; 周桂香; 栾红兵;季静娟; 郑圣霞   

  1. 安徽医科大学附属省立医院生殖中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-01-15 发布日期:2010-01-15

The Effects of Endometriosis Without Ovary Lesions on Ovarian Reserve Function

ZHANG Rong;LIU Yu-sheng;TONG Xian-hong;LUO Li-hua;ZHOU Gui-xiang;LUAN Hong-bing;JI Jing-juan;ZHENG Sheng-xia   

  1. Reproductive Medicine Center，The Province Hospital of Anhui Medical University，Hefei 　230001，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-01-15 Online:2010-01-15

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摘要： 目的：探讨子宫内膜异位症（EMs）与卵巢储备功能下降的相关性。方法：回顾性分析2007年1月—2009年1月就诊的100例不孕妇女，分为两组：A组（50例）是经腹腔镜确诊为EMs但未发现有卵巢病灶者；B组（50例）单纯输卵管性不孕为对照组。测量月经第3天血清卵泡刺激素（FSH）、黄体生成激素（LH）、雌二醇（E2）和卵巢窦卵泡数（AFC）；对比两组体外受精（IVF）过程中的促性腺激素（Gn）用量、获卵数、优质胚胎率、周期删除率、临床妊娠率。结果：A组基础FSH, FSH / LH比值、E2、Gn用量、周期删除率高于B组；AFC和获卵数少于B组，并有统计学意义。基础LH、优质胚胎率、临床妊娠率两组无差别。结论：EMs可加速卵巢储备功能下降。EMs患者应该尽早安排生育，必要时接受IVF。

关键词: 子宫内膜异位症, 卵巢储备功能, 体外受精, 优质胚胎率, 妊娠率

Abstract: Objective: To investigate the relationship between endometriosis without ovary lesions and ovarian reserve function. Methods：Retrospective analysis of 100 infertile women who underwent in vitro fertilization（IVF）from January 2007 to January 2009 in Centre for Reproductive Medicine, Anhui Provincial Hospital. Patients were divided into two groups: group A contained 50 cases of endometriosis without ovary lesions diagnosed by laparoscopy, group B (control group) contained 50 cases of tubal obstruction. Serum FSH, LH, E2 hormone and antral follicular count (AFC) were measured on the day 3 of menses. Number of retrieved oocytes, embryo quality, cycle cancellation rate and clinical pregnancy rates were compared between two groups. Results： Compared to the control group, group A has higher levels of the basis FSH, FSH / LH ratio, E2 and Gn dosage, and cycle cancellation rate, but less AFC and retrieved oocytes,. The differences are statistically significant. Serum LHaccelerate hormone on the day 3 of menses, high-quality embryo rate and pregnancy rate are not different between two groups. Conclusion：Ovarian reserve failure can be accelerated by endometriosis. Women with endometriosis should be advised to conceive and give birth to a child as soon as possible, if necessary, the assisted reproductive technology maybe the best choice.

Key words: Endometriosis, Ovarian reserve, In vitro fertilization, High-quality embryo rate, Pregnancy rate