国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2018, Vol. 37 ›› Issue (3): 257-261.

• 综述 • 上一篇    下一篇

运动对男性生殖影响的研究进展

周伟航，陈少岸，于丰浩，高君达，刘悦，丁之徳   

  1. 200025  上海交通大学医学院临床医学系2015级临床八年制（周伟航，陈少岸，于丰浩，高君达），组织胚胎学与遗传发育学系（刘悦，丁之德）
  • 收稿日期:2018-01-23 修回日期:2018-03-31 出版日期:2018-05-15 发布日期:2018-05-15
  • 通讯作者: 刘悦，E-mail：liuyue@shsmu.edu.cn；丁之德，E-mail：zding@shsmu.edu.cn E-mail:zding@shsmu.edu.cn
  • 基金资助:
    上海交通大学第十一期大学生创新项目（1117020）

Effects of Physical Exercise on Male Reproduction: A Review

ZHOU Wei-hang，CHEN Shao-an，YU Feng-hao，GAO Jun-da，LIU Yue，DING Zhi-de   

  1. Department of Clinical Medicine，Grade 2015（ZHOU Wei-hang，CHEN Shao-an，YU Feng-hao，GAO Jun-da），Department of Anatomy，Histology and Embryology（LIU Yue，DING Zhi-de），School of Medicine，Shanghai Jiao Tong University，Shanghai 200025，China
  • Received:2018-01-23 Revised:2018-03-31 Published:2018-05-15 Online:2018-05-15
  • Contact: LIU Yue，E-mail：liuyue@shsmu.edu.cn；DING Zhi-de，E-mail：zding@shsmu.edu.cn E-mail:zding@shsmu.edu.cn

PDF (PC)

8583

摘要： 运动对男性生殖的作用具有双重性，即合理运动有益于生殖内分泌，超负荷运动却常会损害男性的生育力。合理运动量的体能锻炼，卵泡刺激素（FSH）水平相比锻炼前上升，黄体生成激素（LH）和睾酮（T）水平显著上升；改善睾丸局部微环境，还改变生殖细胞的表观遗传修饰，有利于后代健康。超负荷运动则使睾丸微环境的温度显著上升，热应激可损伤精子的结构和功能并最终导致男性生育力下降；超负荷运动还抑制促性腺激素释放激素（GnRH）神经元和垂体功能，干扰生殖激素分泌。此外，运动还使精子DNA CpG岛相关基因发生明显的去甲基化，影响微小RNA（miRNA）表达水平，影响表观遗传。综述运动对男性生殖的影响及其机制。

关键词: 男（雄）性, 精子发生, 生殖, 运动（Exercise）, 肥胖症

Abstract: The effect of physical exercise on male reproduction is usually dual. Rational exercise is beneficial to reproductive endocrinology, whilst overload exercise usually damages male fertility. Physical exercise at a reasonable amount remarkably increases the levels of FSH, LH and T, improves the microenvironment of the testis, and alters the epigenetic modifications of sperm cells for the benefit of offspring. However, excessive exercise elevates the temperature of the testicular microenvironment, and the induced heat stress can impair the sperm structure and function that eventually lead to male infertility. Furthermore, excessive exercise can also inhibit the functions of GnRH neurons and pituitary and interfere in the secretion of reproductive hormones. Besides, physical exercise causes significant demethylation of genes related to sperm DNA CpG island, which affect the expressions of microRNAs and epigentics. The research progress of the effects of exercise on male reproduction and the underlying mechanisms were discussed in this review.

Key words: Male, Spermatogenesis, Reproduction, Exercise, Obesity