国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (1): 65-69.

• 综述 • 上一篇    下一篇

抗苗勒管激素在卵巢功能及相关疾病中的应用进展

刘云，胡卫华   

  1. 241001 安徽省芜湖市，皖南医学院附属弋矶山医院生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-01-15 发布日期:2016-01-15
  • 通讯作者: 胡卫华

Function of Anti-Mullerian Hormone in Ovary-related Diseases

LIU Yun，HU Wei-hua   

  1. Department of Reproductive Medicine，Yijishan Hospital，Wannan Medical College，Wuhu 241001，Anhui Province，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-01-15 Online:2016-01-15
  • Contact: HU Wei-hua

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摘要： 抗苗勒管激素（anti-Mullerian hormone，AMH）是睾丸支持细胞和卵巢颗粒细胞分泌的一种由二硫键连接两个相同亚基的二聚体糖蛋白，属于转化生长因子β超家族成员，具有调节两性生殖细胞发育的功能。在卵巢功能方面，AM能够调节卵泡发育，参与卵泡生长过程，还能早期评估卵巢储备情况，及早预测绝经年龄，更能早期发现卵巢疾病并评估疾病发展及预后，在辅助生殖技术中亦起到重要作用。随着检测技术的发展，AMH浓度的测量更加简便和精确，而且与其他生物学指标比较，AMH浓度相对稳定，所以AMH已成为近年来的研究热点之一。 就近年来AMH与卵巢功能及相关疾病的关系综述如下。

关键词: 抗苗勒管激素, 卵泡, 卵巢, 卵巢疾病, 生殖技术, 辅助, 绝经期

Abstract: Anti-Mullerian hormone (AMH), a disulfide-linked dimer of two identical subunits of glycoprotein, is secreted by immature testicular Sertoli cell and ovarian granulosa cells, belonging to the transforming growth factor β super-family. One of main physiological functions is regulating the germ cell development. AMH participates in regulating follicular development and growth. AMH has been used to assess ovarian reserve and to predict menopause age. It can be used to detect early ovarian disease and to assess progression and prognosis of disease. In the area of assisted reproductive technology (ART), the application of AMH gets more and more recognition. With the development of analysis technics, AMH test gets more simple and accurate. Compared with other biological indicators, AMH is relatively stable in the different day of menstrual cycle. Now, AMH, as well as its application in ART, has become a hot-topic in recent years. In this paper, we summarized the function of AMH and its clinical application in ovary-related diseases.

Key words: Anti-Mullerian hormone, Ovarian follicle, Ovary, Ovarian diseases, Reproductive techniques, assisted, Menopause