国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (3): 237-239.

• 综述 • 上一篇    下一篇

巨噬细胞移动抑制因子与子宫内膜容受性

唐智华,杨雪峰   

  1. 450052 郑州大学第三附属医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-05-15 发布日期:2011-05-15

Macrophage Migration Inhibitory Factor and Endometrial Receptivity

TANG Zhi-hua, YANG Xue-feng   

  1. Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-05-15 Online:2011-05-15

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摘要： 胚胎植入需要囊胚与子宫内膜同步发育，着床窗口期子宫内膜容受性在植入过程中起关键作用。近年研究发现，许多细胞因子、酶类等与子宫内膜容受性密切相关。巨噬细胞移动抑制因子（macrophage migration inhibitory factor，MIF）是目前公认的一种调节免疫反应的多功能细胞因子。研究发现，MIF可影响整合素和血管内皮生长因子的表达。研究胚胎植入过程中MIF的表达及与相关细胞因子之间的作用，综述MIF与子宫内膜容受性的关系。

关键词: 巨噬细胞游走抑制因子, 子宫内膜容受性, 着床窗口期, 子宫内膜, 胚胎植入

Abstract: Embryo implantation requires blastocyst and endometrium develop synchronously. Endometrial receptivity during the window of implantation plays a key role in embryo implantation. Recent research found that many cytokines, enzymes are closely related to endometrial receptivity. Macrophage migration inhibitory factor is recognized as a multifunctional cytokine in immune response regulation. Recent research found that it may affect the expression of integrin and vascular endothelial growth factor. This review elaborates the relationship between MIF and endometrial receptivity in the process of embryo implantation and the relationships between MIF and some cytokines.

Key words: Macrophage migration inhibitory factors, Endometrial receptivity, Window of implantation, Endometrium, Embryo implantation