子宫内膜干/祖细胞与子宫内膜异位症发病机制的研究进展

doi:10.12280/gjszjk.20200720

摘要/Abstract

摘要：

子宫内膜干/祖细胞的发现为子宫内膜异位症发病机制的研究提供了新的思路。子宫内膜干/祖细胞根据其表面标志物及在人体中功能、位置的不同分为子宫内膜上皮祖细胞、子宫内膜间充质干细胞、侧群细胞、巢细胞等。子宫内膜干/祖细胞的发现完善了Sampson的经血逆流学说,为青春期子宫内膜异位症的发病提供了新的合理的解释。对子宫内膜干/祖细胞的深入研究将为子宫内膜异位症的诊断和治疗提供新的可能。

关键词: 子宫内膜异位症, 子宫内膜, 干细胞, 间充质基质细胞

Abstract:

The endometrial stem/progenitor cells are new targets for the study of the pathogenesis of endometriosis. According to their surface markers and functions in human body, endometrial stem/progenitor cells can be divided into four subgroups: endometrial epithelial progenitor cells, endometrial mesenchymal stem cells, side population cells, niche cells. The discovery of endometrial stem/progenitor cells has improved the Sampson′s theory of retrograde menstruation, and provided a new and reasonable explanation for the pathogenesis of adolescent endometriosis. The further study of endometrial stem/progenitor cells will provide a new possibility for the diagnosis and treatment of endometriosis.

Key words: Endometriosis, Endometrium, Stem cells, Mesenchymal stromal cells

戴垒, 冒韵东. 子宫内膜干/祖细胞与子宫内膜异位症发病机制的研究进展[J]. 国际生殖健康/计划生育, 2021, 40(4): 319-322.

DAI Lei, MAO Yun-dong. Endometrial Stem/Progenitor Cells and the Pathogenesis of Endometriosis[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(4): 319-322.

参考文献 25

[1]	Martin JD Jr, Hauck AE. Endometriosis in the male[J]. Am Surg, 1985, 51(7):426-430.
[2]	Bozorgmehr M, Gurung S, Darzi S, et al. Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application[J]. Front Cell Dev Biol, 2020, 8:497. doi: 10.3389/fcell.2020.00497. doi: 10.3389/fcell.2020.00497 pmid: 32742977
[3]	Hill CJ, Fakhreldin M, Maclean A, et al. Endometriosis and the Fallopian Tubes: Theories of Origin and Clinical Implications[J]. J Clin Med, 2020, 9(6):1905. doi: 10.3390/jcm9061905. doi: 10.3390/jcm9061905 URL
[4]	Gurung S, Deane JA, Masuda H, et al. Stem Cells in Endometrial Physiology[J]. Semin Reprod Med, 2015, 33(5):326-332. doi: 10.1055/s-0035-1558405. doi: 10.1055/s-0035-1558405 URL
[5]	Vasilopoulos E, Fragkiadaki P, Kalliora C, et al. The association of female and male infertility with telomere length (Review)[J]. Int J Mol Med, 2019, 44(2):375-389. doi: 10.3892/ijmm.2019.4225. doi: 10.3892/ijmm.2019.4225 pmid: 31173155
[6]	Nguyen H, Xiao L, Deane JA, et al. N-cadherin identifies human endometrial epithelial progenitor cells by in vitro stem cell assays[J]. Hum Reprod, 2017, 32(11):2254-2268. doi: 10.1093/humrep/dex289. doi: 10.1093/humrep/dex289 URL
[7]	Tempest N, Maclean A, Hapangama DK. Endometrial Stem Cell Markers: Current Concepts and Unresolved Questions[J]. Int J Mol Sci, 2018, 19(10):3240. doi: 10.3390/ijms19103240. doi: 10.3390/ijms19103240 URL
[8]	Liu Y, Niu R, Yang F, et al. Biological characteristics of human menstrual blood-derived endometrial stem cells[J]. J Cell Mol Med, 2018, 22(3):1627-1639. doi: 10.1111/jcmm.13437. doi: 10.1111/jcmm.13437 URL
[9]	Wolmarans E, Nel S, Durandt C, et al. Side Population: Its Use in the Study of Cellular Heterogeneity and as a Potential Enrichment Tool for Rare Cell Populations[J]. Stem Cells Int, 2018, 2018:2472137. doi: 10.1155/2018/2472137. doi: 10.1155/2018/2472137 pmid: 30627171
[10]	Miyazaki K, Maruyama T, Masuda H, et al. Stem cell-like differentiation potentials of endometrial side population cells as revealed by a newly developed in vivo endometrial stem cell assay[J]. PLoS One, 2012, 7(12):e50749. doi: 10.1371/journal.pone.0050749. doi: 10.1371/journal.pone.0050749 URL
[11]	Zhu X, Péault B, Yan G, et al. Stem Cells and Endometrial Regeneration: From Basic Research to Clinical Trial[J]. Curr Stem Cell Res Ther, 2019, 14(4):293-304. doi: 10.2174/1574888X14666181205120110. doi: 10.2174/1574888X14666181205120110 URL
[12]	Yilmaz BD, Bulun SE. Endometriosis and nuclear receptors[J]. Hum Reprod Update, 2019, 25(4):473-485. doi: 10.1093/humupd/dmz005. doi: 10.1093/humupd/dmz005 pmid: 30809650
[13]	Singh A, Yadav CB, Tabassum N, et al. Stem cell niche: Dynamic neighbor of stem cells[J]. Eur J Cell Biol, 2019, 98(2/3/4):65-73. doi: 10.1016/j.ejcb.2018.12.001. doi: 10.1016/j.ejcb.2018.12.001 URL
[14]	López-Pérez N, Gil-Sanchis C, Ferrero H, et al. Human Endometrial Reconstitution From Somatic Stem Cells: The Importance of Niche-Like Cells[J]. Reprod Sci, 2019, 26(1):77-87. doi: 10.1177/1933719118766251. doi: 10.1177/1933719118766251 pmid: 29575998
[15]	Xu S, Chan R, Li T, et al. Understanding the regulatory mechanisms of endometrial cells on activities of endometrial mesenchymal stem-like cells during menstruation[J]. Stem Cell Res Ther, 2020, 11(1):239. doi: 10.1186/s13287-020-01750-3. doi: 10.1186/s13287-020-01750-3 URL
[16]	Li T, He H, Liu R, et al. Isolation and identification of epithelial and stromal stem cells from eutopic endometrium of women with endometriosis[J]. Eur J Obstet Gynecol Reprod Biol, 2014, 178:89-94. doi: 10.1016/j.ejogrb.2014.04.001. doi: 10.1016/j.ejogrb.2014.04.001 URL
[17]	Zubrzycka A, Zubrzycki M, Perdas E, et al. Genetic, Epigenetic, and Steroidogenic Modulation Mechanisms in Endometriosis[J]. J Clin Med, 2020, 9(5):1309. doi: 10.3390/jcm9051309. doi: 10.3390/jcm9051309 URL
[18]	武萌. 31例青春期子宫内膜异位症的临床分析[D]. 长春:吉林大学, 2019.
[19]	Hogg C, Horne AW, Greaves E. Endometriosis-Associated Macrophages: Origin, Phenotype, and Function[J]. Front Endocrinol(Lausanne), 2020, 11:7. doi: 10.3389/fendo.2020.00007. doi: 10.3389/fendo.2020.00007
[20]	Brosens I, Gargett CE, Guo SW, et al. Origins and Progression of Adolescent Endometriosis[J]. Reprod Sci, 2016, 23(10):1282-1288. doi: 10.1177/1933719116637919. doi: 10.1177/1933719116637919 pmid: 27036950
[21]	Brosens I, Muter J, Gargett CE, et al. The impact of uterine immaturity on obstetrical syndromes during adolescence[J]. Am J Obstet Gynecol, 2017, 217(5):546-555. doi: 10.1016/j.ajog.2017. 05.059. doi: S0002-9378(17)30688-9 pmid: 28578177
[22]	Rolla E. Endometriosis: advances and controversies in classification, pathogenesis, diagnosis, and treatment[J]. F1000Res, 2019 Apr 23, 8:F1000 Faculty Rev-529. doi: 10.12688/f1000research.14817.1. doi: 10.12688/f1000research.14817.1
[23]	Canosa S, Moggio A, Brossa A, et al. Angiogenic properties of endometrial mesenchymal stromal cells in endothelial co-culture: an in vitro model of endometriosis[J]. Mol Hum Reprod, 2017, 23(3):187-198. doi: 10.1093/molehr/gax006. doi: 10.1093/molehr/gax006 pmid: 28158750
[24]	Barra F, Scala C, Mais V, et al. Investigational drugs for the treatment of endometriosis, an update on recent developments[J]. Expert Opin Investig Drugs, 2018, 27(5):445-458. doi: 10.1080/13543784.2018.1471135. doi: 10.1080/13543784.2018.1471135 URL
[25]	Liu Y, Lu C, Fan L, et al. MiR-199a-5p Targets ZEB1 to Inhibit the Epithelial-Mesenchymal Transition of Ovarian Ectopic Endometrial Stromal Cells Via PI3K/Akt/mTOR Signal Pathway In Vitro and In Vivo[J]. Reprod Sci, 2020, 27(1):110-118. doi: 10.1007/s43032-019-00016-5. doi: 10.1007/s43032-019-00016-5 URL