自体外周血单个核细胞治疗不明原因反复种植失败的研究进展

doi:10.12280/gjszjk.20230176

摘要/Abstract

摘要：

反复种植失败（recurrent implantation failure，RIF）给不孕症夫妇带来了巨大的经济及心理负担，在排除已知母胎因素后，不明原因RIF的发生率仍较高，目前认为免疫因素是其潜在原因之一，胚胎种植成功与否取决于母体局部的免疫耐受。外周血单个核细胞（peripheral blood mononuclear cell，PBMC）含有T淋巴细胞、B淋巴细胞和单核细胞等，宫腔灌注自体PBMC可以恢复免疫平衡，提高子宫内膜容受性和着床率。目前，自体PBMC宫腔灌注疗法作为一种潜在治疗不明原因RIF的新型方案，已经取得了一定的进展，但其作用机制尚未明确，且治疗效果存在争议。此外，PBMC的培养方式、宫腔灌注细胞数量、灌注时机和适用人群仍需进一步探索。

关键词: 反复种植失败, 胚胎移植, 外周血单个核细胞, 免疫疗法, 投药，局部, 免疫耐受, 妊娠结局

Abstract:

Recurrent implantation failure (RIF) brings huge economic and psychological burden to infertile couples. After excluding the known maternal-fetal factors, the incidence of unexplained RIF is still high. It is believed that immune factor is one of the potential causes. The success of embryo implantation depends on the local immune tolerance of the mother. Peripheral blood mononuclear cell (PBMC) contain T lymphocytes, B lymphocytes and monocytes. Intrauterine infusion of autologous PBMC can restore the immune balance and improve the endometrial receptivity and the implantation rate. Nowdays, the therapy with autologous PBMC intrauterine infusion has made some progress as a new potential treatment for unexplained RIF. However, the mechanism of therapeutic action is not yet clear, even the therapeutic effect is controversial. In addition, the culture method of PBMC, the number of intrauterine infusion cells, the timing of infusion and the applicable population still need to be further explored.

Key words: Recurrent implantation failure, Embryo transfer, Peripheral blood mononuclear cell, Immunotherapy, Administration, topical, Immune tolerance, Pregnancy outcome

李宁, 张安妮, 张学红. 自体外周血单个核细胞治疗不明原因反复种植失败的研究进展[J]. 国际生殖健康/计划生育杂志, 2023, 42(5): 403-408.

LI Ning, ZHANG An-ni, ZHANG Xue-hong. Research Progress of Autologous Peripheral Blood Mononuclear Cell in the Treatment of Unexplained Recurrent Implantation Failure[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(5): 403-408.

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