槲皮素对多囊卵巢综合征的潜在治疗作用

doi:10.12280/gjszjk.20250074

摘要/Abstract

摘要：

多囊卵巢综合征（polycystic ovary syndrome，PCOS）是育龄期女性常见的多系统疾病之一，常常伴有代谢、生殖异常。近年来，对PCOS患者伴发异常心理状态、不良妊娠结局及远期并发症的关注日益增加。槲皮素（quercetin，QUE）作为一种天然黄酮类化合物，在PCOS的治疗中展现出独特潜力。在代谢调节方面，QUE能通过多途径改善胰岛素抵抗，调节糖脂代谢。在生殖内分泌方面，QUE能显著降低血清雄激素水平，通过减少卵泡闭锁和促进卵泡成熟来改善排卵障碍，从而恢复卵巢正常功能。在生殖结局方面，QUE可能通过抗炎、抗氧化应激和抗凋亡等特性，降低流产发生。此外，QUE还具有抗抑郁、抗癌的特性，防治PCOS患者并发焦虑抑郁和子宫内膜癌。未来仍需要更多的研究为QUE的临床应用提供支持。

关键词: 多囊卵巢综合征, 槲皮素, 胰岛素抵抗, 抑郁, 流产, 子宫内膜肿瘤

Abstract:

Polycystic ovary syndrome (PCOS), a common multisystem disorder in women of reproductive age, is typically associated with metabolic and reproductive abnormalities. In recent years the attention to the psychological disturbances, adverse pregnancy outcomes, and long-term complications in PCOS patients has been growing. Quercetin (QUE) as a natural flavonoid exhibits the unique therapeutic potential for PCOS management. In terms of metabolic regulation, QUE can improve insulin resistance and modulates glucose/lipid metabolism through multiple pathways. Regarding reproductive endocrinology, QUE can significantly reduce serum androgen level, mitigate follicular atresia and promote follicular maturation, thereby restore normal ovarian function and alleviae ovulatory dysfunction. As for reproductive outcomes, QUE may reduce miscarriage risk via anti-inflammatory, antioxidant and anti-apoptotic properties. Additionally, QUE may have the effects of anti-depressant and anti-cancer, potentially preventing anxiety/depression and endometrial cancer in PCOS patients. While preclinical evidence supports QUE′s multifaceted benefits in PCOS, further clinical studies are needed to validate its therapeutic applications.

Key words: Polycystic ovary syndrome, Quercetin, Insulin resistance, Depression, Abortion, Endometrial neoplasms

余健楠, 高竹薇, 葛航, 刘洋, 石百超, 白宇鑫, 高敬书, 王宇, 吴效科. 槲皮素对多囊卵巢综合征的潜在治疗作用[J]. 国际生殖健康/计划生育杂志, 2025, 44(5): 393-398.

YU Jian-nan, GAO Zhu-wei, GE Hang, LIU Yang, SHI Bai-chao, BAI Yu-xin, GAO Jing-shu, WANG Yu, WU Xiao-ke. The Potential Therapeutic Role of Quercetin in Polycystic Ovary Syndrome[J]. Journal of International Reproductive Health/Family Planning, 2025, 44(5): 393-398.

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