益生菌治疗多囊卵巢综合征的研究进展

doi:10.12280/gjszjk.20250235

摘要/Abstract

摘要：

多囊卵巢综合征（polycystic ovary syndrome，PCOS）是育龄期女性常见的生殖内分泌代谢性疾病，以高雄激素血症、排卵功能障碍和多囊卵巢形态为主要特征。其发病机制复杂，目前尚不明确。PCOS临床表现具有高度异质性，治疗多以改善临床症状为主。近年随着对肠道菌群与PCOS关系的深入研究，益生菌在PCOS治疗中的应用逐渐受到关注。益生菌能够调整肠道微生物组，通过胆汁酸去结合作用降低胆固醇，调节体质量和血清脂质水平，降低血压，并预防和治疗感染。益生菌可改善胰岛素抵抗、调节激素紊乱、减轻氧化应激和炎症、改善脂质代谢异常和生殖功能、提高心理健康水平等，对PCOS患者起到治疗作用。

关键词: 多囊卵巢综合征, 鼠李糖乳杆菌, 胃肠道微生物组, 胰岛素抵抗, 治疗

Abstract:

Polycystic ovary syndrome (PCOS), a common reproductive endocrine metabolic disorder among women of childbearing age, is characterized by hyperandrogenemia, ovulatory dysfunction, and the presence of multiple cystic ovaries. The pathogenesis of PCOS is complex and unclear. The clinical manifestations of PCOS are highly heterogeneous, and treatment mainly focuses on alleviating clinical symptoms. In recent years, with the in-depth study of the relationship between the gut microbiota and PCOS, the application of probiotics in the treatment of PCOS has gradually gained attention. Probiotics can adjust the intestinal microbiome, reduce cholesterol through bile acid deconjugation, regulate body weight and serum lipid levels, lower blood pressure, and prevent and treat infections. Probiotics can improve insulin resistance, regulate hormonal disorders, alleviate oxidative stress and inflammation, improve abnormal lipid metabolism and reproductive function, and enhance mental health levels, all of which have therapeutic effects on PCOS patients.

Key words: Polycystic ovary syndrome, Lactobacillus rhamnosus, Gastrointestinal microbiome, Insulin resistance, Therapy

牛佳佳, 王宇, 吴效科. 益生菌治疗多囊卵巢综合征的研究进展[J]. 国际生殖健康/计划生育杂志, 2025, 44(5): 399-404.

NIU Jia-jia, WANG Yu, WU Xiao-ke. Research Progress on Probiotic Therapy for Polycystic Ovary Syndrome[J]. Journal of International Reproductive Health/Family Planning, 2025, 44(5): 399-404.

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