国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (3): 191-195.

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卵巢储备功能减退患者再生育的治疗策略

马翔，刘嘉茵   

  1. 210029 南京医科大学第一附属医院临床生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-05-15 发布日期:2016-05-15
  • 通讯作者: 刘嘉茵

The Treatment Strategy in Rebirth Patients with Diminished Ovarian Reserve

MA Xiang, LIU Jia-yin   

  1. Center of Clinical Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-05-15 Online:2016-05-15
  • Contact: LIU Jia-yin

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摘要： 全面二孩政策放开，相当一部分再生育女性进入卵巢储备功能减退（DOR）的年龄。DOR预示卵巢对药物刺激的反应下降，卵母细胞质量不良，发生“受孕难，易流产”的现象，准确、及时评估卵巢储备功能对于拟生育人群至关重要。目前针对DOR人群的生育策略包括：①积极采用辅助生殖技术助孕，其中温和刺激、微刺激或自然周期方案已成为DOR人群的重要方案；②辅以添加生长激素、弱雄激素、抗氧化剂提高助孕成功率；③赠卵体外受精（卵子库的建设）及生殖工程技术。即使先进的助孕技术，对由于年龄原因导致的DOR，仍然很难获得良好的临床妊娠结局。

关键词: 再生育, 生育力, 卵巢储备功能减退, 卵巢, 生殖技术, 辅助

Abstract: With the universal two-child policy in China, a considerable part of the rebirth patients are coming into the age of ovarian reserve function decline (DOR) at present. DOR indicates the decreasing reaction to ovarian stimulation, the decreasing quality of oocyte, and the status of "hard to pregnancy and easy to abortion". It is very important to assess accurately and promptly the ovarian reserve of DOR rebirth patients. At present, the treatment strategy for DOR patients includes: ①Assisted reproductive technology(ART) is recommended actively, in which the mild stimulation, minimal stimulation or natural cycles is the increasing popular ART strategy in DOR patients; ②Growth hormones, weak androgens and antioxidants can be added to improve the clinical outcomes of in vitro fertilization (IVF); ③The clinical outcomes could be still unsatisfied for those aged DOR patients even if the donated egg IVF combined with reproductive engineering technology was used.

Key words: Rebirth, Fertility, Diminished ovarian reserve, Ovary, Reproductive techniques, assisted