国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (2): 99-104.

• 论著 • 上一篇    下一篇

紫河车治疗国人卵巢功能早衰的系统评价

胡颖,许良智 ,李文娟   

  1. 610041成都，四川大学华西第二医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-03-15 发布日期:2012-03-15
  • 通讯作者: 许良智

Placenta Hominis in Treatment of Premature Ovarian Failure of Chinese People: a Systematic Review

HU Ying，XU Liang -zhi，LI Wen -juan   

  1. Department of Obstetrics and Gynecology，West China Second Hospital，Sichuan University，Chengdu 610041，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-03-15 Online:2012-03-15
  • Contact: XU Liang-zhi

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摘要： 目的：系统评价在中国紫河车治疗卵巢功能早衰的有效性和安全性。方法：采用Cochrane系统评价法，检索Cochrane图书馆临床对照试验数据库，All EBM Reviews，Embase，PubMed，MEDLINE和 CNKI等数据库，纳入紫河车治疗卵巢功能早衰的随机/半随机对照试验，不限语种。评价纳入研究的方法学质量，应用RevMan 5.0.25软件对有关数据进行Meta分析。结果：本研究共纳入相关文献2篇，135例患者，纳入研究的方法学质量整体偏低。与西药组相比，紫河车结合西药人工周期组月经改善率高于对照组，差异有统计学意义（RR=1.47，95% CI：1.19~1.82，P=0.0004），血清雌二醇（E2）水平改善明显高于西药组，异有统计学意义[加权均数差（WMD）=-42.29，95% CI：-56.45~-28.13，P约0.000 01]。其他方面差异均无统差计学意义。结论：紫河车结合西药人工周期疗法比单纯的西药人工周期疗法改善卵巢功能早衰患者的月经恢复和血清激素水平的疗效好。但目前尚无充分证据证明，单纯紫河车治疗国人卵巢功能早衰的有效性和安全性优于激素治疗等西医治疗方法，尚待更多严格设计的随机对照试验、样本量较大的临床试验加以证实和重新评价。

关键词: 紫河车, 卵巢功能早衰, 系统评价, 中国

Abstract: Objective：To assess the effectiveness and safety of Placenta Hominis in treatment of premature ovarian failure of Chinese people. Methods：A systematic review and meta -analysis of the randomized/semi -randomized controlled trials was designed to study Placenta Hominis used for treatingpremature ovarian failure. Articles were searched from The Cochrane Library, All EBM Reviews, EMBASE,PUBMED, MEDLINE, CNKI, etc. RevMan 5.0.25 recommended by The Cochrane Collaboration was used toconduct this systematic review and meta -analysis. Results：Two trials including 135 patients were included.The methodological quality of two studies was low. The menses recovery rate in the group treated with PlacentaHominis combined with artificial menstrual cycle was significantly higher than that in the control group treatedwith simple artificial menstrual cycle（RR=1.47，95%CI：1.19耀1.82，P=0.0004）.The change of serum E2 levelin the group treated with Placenta Hominis combined with artificial menstrual cycle was also better than that inthe control group（WMD =原42.29，95% CI：-56.45耀-28.13，P<0.000 01）. Conclusions：In the treatment of premature ovarian failure, Placenta Hominis combined with artificial menstrual cycle hada relatively highermenses recovery rate and better serumE2 level than the control group. It can not be concluded at present thatPlacenta Hominis is better than the hormonal treatment. More evidence from the high quality, randomizedplacebo controlled trials is needed to assess the effectiveness and safety of traditional Chinese herbals, such asPlacenta Hominis, in treating premature ovarian failure.

Key words: PLACENTA HOMINIS, Ovarian failure, premature, Systematic review, China