国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (3): 218-221.

• 论著 • 上一篇    下一篇

复方炔诺酮避孕片与女性高血压风险的关系

陈 晗, 李 瑛, 钱卫冲, 赵金扣, 孙志明, 吴玉璘 ,周 健, 巴 磊   

  1. 210036 南京，江苏省计划生育科学技术研究所，国家人口计生委计划生育药具不良反应监测中心（陈 晗，李 瑛，孙志明，吴玉璘，周 健，巴 磊）；江苏省人民医院（钱卫冲）；江苏省疾病预防控制中心（赵金扣
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-05-15 发布日期:2011-05-15
  • 通讯作者: 李 瑛

Association Between Combined Norethisterone Oral Contraceptives and Risks of Female Hypertension

CHEN Han， LI Ying， QIAN Wei-chong， ZHAO Jin-kou， SUN Zhi-ming， WU Yu-lin， ZHOU Jian， BA Lei   

  1. Jiangsu Institute of Planned Parenthood Research，NPFPC Contraceptives Adverse Reaction Surveillance Center， Nanjing 210036， China（CHEN Han， LI Ying， SUN Zhi-ming， WU Yu-lin， ZHOU Jian， BA Lei）；Jiangsu Province Hospital， Nanjing 210029， China（QIAN Wei-chong）； Jiangsu Provincial Center for Disease Prevention and Control， Nanjing 210009， China（ZHAO Jin-kou）
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-05-15 Online:2011-05-15
  • Contact: LI Ying

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摘要： 目的：研究复方炔诺酮避孕片（1号避孕片）与女性高血压风险的关系，以期降低不良反应。方法：采用横断面研究的方法，使用统一的调查问卷、体格检查表对符合入选标准的已婚妇女进行集中调查，采用Logistic回归分析高血压患病因素。结果：①5 596例已婚妇女中患高血压者占12.10%（677例）。②与放置宫内节育器（IUD）妇女比较，曾经服用1号避孕片10~19年和20年以上的妇女患高血压的风险略有升高（调整RR=1.48，95% CI：1.08~2.03；调整RR=1.63，95% CI：1.17~2.27），正在服用1号避孕片10~19年和≥20年的妇女患高血压的风险也略有升高（调整RR=1.53，95% CI：1.16~2.59；调整RR=1.80，95% CI：1.12~2.90）；③高血压患病的危险因素按标化回归系数绝对值大小排列依次为体质量指数升高、有心脑血管疾病家族史、年龄和使用口服避孕药等。结论：长期使用1号避孕片女性患高血压病风险增加，应对其加强血压水平的随访和医学监护，提高使用口服避孕药的安全性和有效率。

关键词: 炔诺酮, 避孕药, 口服, 复合, 避孕药, 女性, 高血压, 危险因素

Abstract: Objective：To assess the association between combined norethisterone oral contraceptives（OC）and the risk of female hypertension so as to decrease the adverse reactions of OC. Methods：In June 2003， a cross-sectional study was conducted to invest the qualified and married women in Shaxi Town of Taicang County by unified questionnaire and physical examination tables. Logistic regression was used to analyze the prevalence factors of hypertension. Results：①The hypertension prevalence among 5 596 women was 12.10%（677 women）.② Compared with those subjects with IUDs, the risk of hypertension prevalence was increased slightly among those who had ever used OC over 20 years（adjusted RR=1.63， 95% CI was 1.17～2.27）， the risk was also slightly higher among those who was taking OC over 20 years（adjusted RR=1.80， 95%CI was 1.12～2.90）。③According to the standarded coefficient of regression, the risk factors of hypertension were ordered as: increased body mass index， family history of cerebrovascular diseases， age increasing， OC use， etc. Conclusions： There is an increase in the risk of hypertension among long?-term users of OC. The results suggested that follow-up of blood pressure and medical care should be strengthened in OC users，so as to improve the safety and efficiency of OC use.

Key words: Norethindrone, Contraceptives, oral, Combined, Contraceptive agents, female, Hypertension, Risk factors