国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (1): 18-21.

• 综述 • 上一篇    下一篇

雄性生殖中热休克蛋白作用的研究进展

朱晔敏综述;丁之德审校

  

  1. 上海交通大学医学院组织胚胎学教研室
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-01-15 发布日期:2010-01-15

Heat Shock Protein in Male Reproduction

ZHU Ye-min;DING Zhi-de   

  1. Department of Histology and Embryology, School of Medicine, Shanghai Jiao Tong University
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-01-15 Online:2010-01-15

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摘要： 热休克蛋白(heat shock protein，HSP)是指所有生物细胞在应激原刺激后，发生热休克反应时产生的一类细胞伴侣蛋白的总称。该类蛋白在细胞生命过程中可参与蛋白的折叠、装配及运输等活动，对调控细胞的生长、存活及分化起着重要作用。在哺乳动物的雄性生殖领域，HSP家族参与精子发生、精卵结合、精子获能及受精等一系列活动，与雄性生殖过程密切相关。因此，研究HSP家族在雄性生殖中的生物学作用对进一步阐明男性不育的发病机制及后续男性生殖调节的研究都具有十分重要的意义。

关键词: 热休克蛋白, 雄性生殖, 精子, 受精, 男性不育

Abstract: Heat Shock Protein (HSP) is one kind of cell chaperone protein generated when cell occurs a heat shock reaction after being stimulated by stressors. During the cell differentiation and proliferation, HSPs are involved in the processes of protein folding, assembly, transport and other activities which play an important role in cell growth and survival. In the field of mammalian male reproduction, HSP family participates in a series of activities such as spermatogenesis, sperm capacitation, sperm-egg binding and fertilization. Thus, to investigate the biological function of HSP family in male reproduction will not only elucidate the mechanism of male infertility but also further regulate male reproduction.

Key words: Heat shock proteins (HSP), Male reproduction, Spermatozoa, Fertilization, Male infertility