国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (1): 22-25.

• 综述 • 上一篇    下一篇

输卵管积水状态下的子宫内膜容受性

成芳综述;蔡霞审校

  

  1. 新疆医科大学第一附属医院生殖助孕中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-01-15 发布日期:2010-01-15

Effects of Hydrosapinx on Endometrial Receptivity

CHENG Fang;CAI Xia   

  1. Reproductive Center of the First Affiliated Hospital of Xinjiang Medical University
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-01-15 Online:2010-01-15

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摘要： 因输卵管因素导致的不孕症是体外受精－胚胎移植（IVF-ET）的适应证之一。其中，未经处理的输卵管积水患者在接受IVF治疗后胚胎种植率和临床妊娠率均下降，自然流产率增加。推测输卵管积水可能影响胚胎质量和子宫内膜容受性。从超声学和分子生物学方面就输卵管积水对子宫内膜容受性的影响相关研究做文献综述。

关键词: 输卵管积水, 子宫内膜容受性, 整合素, HOXA10

Abstract: IVF/ET is a better alternative to those patients with severe distal tubal disease. However, the presence of hydrosalpinx has a negative effect on IVF/ET by decreasing the pregnancy rates and implantation rates compared with patients undergoing IVF/ET for tubal disease without hydrosalpinx. The hydrosalpingeal fluid has been demonstrated to be embryotoxic to developing embryos. Poor endometrial receptivity has also been demonstrated in the presence of hydrosalpinges. This article reviewed the latest progress of hydrosalpinx on endometrial receptivity from two aspects: ultrasonic parameters and molecular biological parameters .

Key words: Hydrosapinx, Endometrial receptivity, Integrin, HOXA10