国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (6): 479-483.

• 综述 • 上一篇    下一篇

卵巢功能早衰的研究进展

包 蕾,张绍芬,张月萍   

  1. 200011 上海，复旦大学附属妇产科医院（包 蕾，张绍芬）；上海集爱遗传与不育诊疗中心（张月萍）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-11-15 发布日期:2011-11-15

Research Progression in Primary Ovarian Failure

BAO Lei， ZHANG Shao-fen， ZHANG Yue-ping   

  1. Obstetrics and Gynecology Hospital of Fudan University， Shanghai 200011， China（BAO Lei， ZHANG Shao-fen）； ShangHai JiAi Genetics and IVF Institute， Shanghai 200011， China（ZHANG Yue-ping）
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-11-15 Online:2011-11-15

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摘要： 卵巢功能早衰是女性不孕的常见病因之一，其发病率有逐年上升的趋势。其病因包括染色体缺陷、自身免疫性疾病、接受放疗或化疗、外科手术及某些药物等，但大多数病例仍病因不明。抑制素及血清抗苗勒管激素可用于早期预测卵巢功能早衰。卵巢功能早衰的诊断基于40岁前发生闭经并伴随卵泡刺激素升高至绝经水平。其治疗主要涉及激素替代疗法和不孕治疗。唯一被确证有效的治疗不孕的方法是赠卵辅助生殖技术。

关键词: 卵巢功能早衰, 诊断, 预测, 治疗, 激素替代疗法, 生殖技术, 辅助

Abstract: Primary ovarian failure（ＰＯＦ） is a common cause of female infertility， with the incidence ascending year by year. The known causes of POF include chromosomal defects， autoimmune diseases，exposure to radiation or chemotherapy， surgical procedures， and some drugs. Even so， the majority of patients could have no etiological evidence. Inhibin and Anti Mullerian Hormone could be used as marks for presymptomatic diagnosis of POF. The diagnosis is based on the amenorrhea before age 40 associated with the elevated FSH levels in the menopausal range. Management essentially involves hormone replacement and infertility treatment. Oocyte donation is the only proven means for infertility treatment of POF.

Key words: Ovarian failure, premature, Diagnosis, Forecasting, Therapy, Hormone replacement therapy, Reproductive techniques, assisted