国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2014, Vol. 33 ›› Issue (6): 462-464.

• 综述 • 上一篇    下一篇

DNA甲基化与男性不育关系的研究进展

王琳琳，徐家伟，孙莹璞   

  1. 450052 郑州大学第一附属医院生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-11-15 发布日期:2014-11-15
  • 通讯作者: 孙莹璞

Research Progress of Relationship between DNA Methylation and Male Infertility

WANG Lin-lin，XU Jia-wei，SUN Ying-pu   

  1. Reproductive Center，The First Affiliated Hospital of Zhengzhou University，Zhengzhou 450052，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-11-15 Online:2014-11-15
  • Contact: SUN Ying-pu

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摘要： 在严重的精子缺乏患者中普遍存在异常的表观遗传变化，已经发现亚甲基四氢叶酸还原酶（MTHFR）、PAX8、NTF3、SFN、HRAS、JHM2DA等基因DNA甲基化改变与不育患者中异常的精液参数有关，这些基因通常是高甲基化的。甲基化和去甲基化的正确调控对个体正常发育至关重要，微小的DNA甲基化异常与许多疾病有关，包括男性不育。阐述男性生殖细胞中正常的DNA甲基化，并对已经发现的异常DNA甲基化和男性不育的关系进行综述，从中探究男性不育的某些遗传学病因。

关键词: 后成说, 遗传, DNA甲基化, 不育, 男（雄）性, 生殖技术, 辅助, 表观遗传学

Abstract: Epigenetic changes are commonly found in those patients with server oligozoospermic and non-obstructive azoospermia. It was found that there was correlationship between the increased DNA methylationes of MTHFR, PAX8, NTF3, SFN, HRAS, JHM2DA, and the abnormal seminal parameters of those infertile patients. It is very important to regulate accurately the methylation and demethylation of those genes for individual development. Any tiny abnormality in DNA methylation could be related to many diseases, including male infertility. In this review, we explored some epigenetic pathogenesis of male infertility by introducing the normal DNA methylation of male germ cell and discussing the relationship between abnormal DNA methylation and male infertility.

Key words: Epigenesis, genetic, DNA methylation, Infertility, male, Reproductive techniques, assisted, Epigenetics