国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (4): 301-304.

• 综述 • 上一篇    下一篇

空通气孔同源框2在生殖医学领域的研究进展

刘 娜，蔡 霞   

  1. 830054 乌鲁木齐，新疆医科大学第一附属医院生殖中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-07-15 发布日期:2013-07-15
  • 通讯作者: 蔡 霞

The Empty Spiracles Homeobox 2 in Reproductive Medicine: A Review

LIU Na，CAI Xia   

  1. The Reproductive Center of the First Affiliated Hospital of Xinjiang Medical University，Urumqi 830054，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-07-15 Online:2013-07-15
  • Contact: CAI Xia

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摘要： 空通气孔同源框2（empty spiracles homeobox 2，EMX2）是人类与果蝇ems（empty spiracles）的同源结构域基因，含同源转录因子。人类泌尿生殖系统与骨盆的正常发育都离不开EMX2基因的调控。EMX2表达于成人的生殖道并呈周期性变化，使子宫内膜得以正常的增殖、蜕膜化，而且影响着胚胎性腺中上皮细胞极性和表皮生长因子受体的表达。EMX2上游基因包括同源盒基因A10（HOXA10）、Spastin和生长素等，而其下游基因调控研究较少。EMX2与子宫内膜异位症的发生亦有联系。随着不断的研究和探索，相信EMX2基因在不孕症、辅助生殖技术等方面的基础研究和临床应用都能得到较大的突破。

关键词: 基因, 同源盒, 泌尿生殖系统, 骨盆, 子宫内膜异位症, 生殖技术, 辅助, 不育, 女（雌）性

Abstract: The empty spiracles homeobox 2 （EMX2） is homolog of the Drosophila head gap gene empty spiracles（ems） homeobox gene. The normal developments of human urogenital system and pelvis are dependent on the regulation of EMX2. EMX2 expressed in adult reproductive tract with cyclical changes，which regulated normal endometrial remodeling and blastocyst implantation. The upstream genes of EMX2 are HOXA10，Spastin and Ghrelin，while the downstream genes of EMX2 were reported less. EMX2 is related to the occurrence of endometriosis. With continuous study in future，we believe that the effect of EMX2 gene，as well as its clinical application in infertility and ART，will be revealed.

Key words: Genes, homeobox, Urogenital system, Pelvis, Endometriosis, Reproductive techniques, assisted, Infertility, female