国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (1): 26-29.

• 综述 • 上一篇    下一篇

双酚A对生殖系统的影响及其作用机制

秦定霞综述;崔毓桂;刘嘉茵审校

  

  1. 南京医科大学第一附属医院临床生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-01-15 发布日期:2010-01-15
  • 通讯作者: 刘嘉茵

The Effect and Mechanism of Bisphenol A on the Reproductive System

QIN Ding-xia;CUI Yu-gui;LIU Jia-yin   

  1. Center of Clinical Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-01-15 Online:2010-01-15
  • Contact: LIU Jia-yin

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摘要： 双酚A（Bisphenol A，BPA）是酚类环境雌激素中的一种，人群暴露剂量的BPA会对机体产生一定的影响，主要包括生殖系统、胚胎发育、中枢神经系统、肿瘤的发生等。而对生殖系统的研究尤为广泛，BPA可引起雄性哺乳动物性腺发育不良、精子数量减少等，引起雌性哺乳动物阴道、子宫、卵巢等形态及功能上的改变。BPA对生殖系统影响的机制多样化，可能通过以下几个途径发挥作用：雌激素核受体及膜受体、雌激素相关受体、下丘脑-垂体-性腺轴等。综述双酚A对生殖系统的影响及其可能的作用机制。

关键词: 双酚A, 生殖系统, 雌激素受体, 非基因组效应

Abstract: Bisphenol A (Bisphenol A, BPA) is one of the phenolic environmental estrogens, exposured to doses of BPA would have certain impact on the organism, including the reproductive system, embryonic development, central nervous system, the occurrence of tumors etc. Especially on the reproductive system, BPA may act on the male mammal,such as gonadal dysgenesis, decrease in the number of sperm etc.At the same time, BPA may act on the female mammals ,changed the morphology and function of vagina, uterus, ovary etc.The effect of BPA on the reproductive system through several pathways,BPA may play a role through the following ways: estrogen nuclear receptor and membrane receptor、estrogen-related receptor、the hypothalamus - pituitary - gonadal axis. This paper reviewed bisphenol A on the reproductive system and its possible mechanism .

Key words: Bisphenol A, Reproductive system, Estrogen receptor, Non-genomic effects