国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (5): 405-407.

• 综述 • 上一篇    下一篇

体外受精-胚胎移植中卵巢低反应的治疗进展

张慧娟,宋学茹   

  1. 300052 天津医科大学总医院妇产科生殖中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-09-15 发布日期:2012-09-15
  • 通讯作者: 张慧娟

Therapy for the Poor Ovarian Responses in IVF -ET

ZHANG Hui-juan，SONG Xue -ru   

  1. Tianjin Medical University General Hospital，Tianjin 300052，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-09-15 Online:2012-09-15
  • Contact: ZHANG Hui-juan

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摘要： 卵巢低反应是体外受精-胚胎移植（IVF-ET）过程中超促排卵的难题，表现为卵巢在超促排卵中效果不理想，以超促排卵后获卵子数目少和血雌二醇（E2）水平低为特征，常导致患者取消治疗周期，其发生率约占接受IVF 治疗妇女的9%耀24% 。卵巢低反应的机制尚不明确，目前诊断标准不统一。卵巢低反应的原因多种多样，研究人员一直在考虑使用不同的药物和方案改善这部分患者的治疗结局：淤增加促性腺激素的用量。于垂体降调节方式。盂添加雄激素。榆添加生长激素。虞采用自然周期或微刺激方案。愚使用口服避孕药、雌激素。尽管处理不良反应的方法很多，但目前仍缺乏能有效逆转卵巢对超促排卵反应不良的方法，采用一种适合的个体化方案可能是在这种困境当中的唯一选择。

关键词: 受精, 体外, 胚胎移植, 生殖技术, 辅助, 卵巢功能早衰

Abstract: The poor ovarian response, a problem of controlled ovarian hyperstimulation in IVF-ET, ischaracteristic of the poor outcome of ovarian hyperstimulation failure, the limited number of recruit follicles, andlowerE2 level, which often leads to the cycle cancel of IVF-ET. The incidence of poor response in IVF-ET is9% to 24% . The mechanism of poor ovarian response is not well clarified; even the diagnosis standard isskimble-scamble. Various treatment protocols were proposed to improve the ovarian reactivity of patients withthe poor ovarian response. These protocols were listed as follows：淤Increasing the stimulation dose of rFSH. 于Pituitary down regulation. 盂The use of androgens or androgen-modulating agents. 榆Administration of growth hormone. 虞Modified natural cycle IVF. 愚Adjuvant therapy such as the use of oral contraceptive pill（COCP），E2. There is little understanding which one is the best protocol to treat effectively the poor ovarian response. Itcould be a feasible choice for different individual to havea suitable and personalized protocol.

Key words: Fertilization in Vitro, Embryo transfer, Reproductive techniques, assisted, Ovarian failure, premature