国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2012, Vol. 31 ›› Issue (5): 413-416.

• 综述 • 上一篇    下一篇

Th17细胞与原因不明复发性流产关系的研究进展

黄颖,徐望明   

  1. 武汉大学人民医院生殖中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-09-15 发布日期:2012-09-15
  • 通讯作者: 徐望明

Relationship Between Th17 Cells and Unexplained Recurrent Spontaneous Abortion

HUANG Ying，XUWang-ming   

  1. Reproductive Medicine Center，Renmin Hospital of Wuhan University，Wuhan 430060，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-09-15 Online:2012-09-15
  • Contact: XUWang-ming

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摘要： Th17 细胞是近年新发现的不同于Th1 和Th2的Th细胞亚群，具有强大的促炎作用，参与许多自身免疫性疾病及急性排斥反应的发生、发展。Th1/Th2/Th17 及Treg 细胞的新平衡模式逐渐取代Th1/Th2 细胞平衡模式，在维持妊娠期免疫耐受中起着至关重要的作用。原因不明复发性流产（URSA）作为临床常见疾病，其免疫学发病机制至今尚未阐明。Th17 细胞的出现为探索URSA 的病因及其治疗提供了新的靶点和研究方向。

关键词: T淋巴细胞, 调节性, 免疫耐受, 妊娠, 流产, 习惯性, 白细胞介素类

Abstract: T helper 17 （Th17）cells were recently found to bea subgroup of independent T cells, whichare distinct from Th1 and Th2 cells. Th17 may play an important role in the inflammation development related topathogenetic mechanism of autoimmune diseases and acute transplant rejection. Now，the new Th1/Th2/Th17 and Treg balance model has replaced the Th1/Th2 paradigm，which is considered to play an essential role in maintaining the immune tolerance during pregnancy. As a common disease in clinical，the immunological pathogenesis of unexplained recurrent spontaneous abortions （URSA）is still unknown. Th17 cells could provide us a new research target on the pathogenesis and treatment of URSA.

Key words: T-lymphocytes, regulatory, Immune tolerance, Pregn, Abortion, habitual, Interleukins