国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (5): 394-396.

• 综述 • 上一篇    下一篇

多囊卵巢综合征发病机制研究新进展

郑若姮,丁彩飞   

  1. 310013 杭州市红十字会医院生殖医学中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-09-15 发布日期:2011-09-15

Progress in the Mechanism of Polycystic Ovary Syndrome

ZHENG Ruo-heng， DING Cai-fei

  

  1. Reproductive Medicine Center， the Red Cross Hospital of Hangzhou， Hangzhou 310013， China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-09-15 Online:2011-09-15

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摘要： 多囊卵巢综合征（PCOS）是不排卵性不孕症的主要病因，主要表现为持续排卵障碍、高雄激素血症及胰岛素抵抗。育龄妇女PCOS患病率为5%~10%，但具体机制未明。近年来，随着各种研究手段特别是高通量测序技术的发展，对PCOS的研究也不断深入。现从遗传因素、易感基因、环境心理因素及代谢综合征等方面系统回顾近年来PCOS发病机制的研究新进展，以期为PCOS防治提供有力的理论依据。

关键词: 多囊卵巢综合征, 代谢综合征, 不育, 女（雌）性, 基因

Abstract: Polycystic ovary syndrome（PCOS） is the major cause of ovulation failure induced infertility， which is characterized by continuous ovulation obstacles，hyperandrogenemia and insulin resistance. The prevalence of PCOS is approximately 5%~10%. The etiology and pathogenesis of PCOS are still unknown. With the technique development，especially the emergence of high throughout sequence platform，research on PCOS has been revolutionized. We reviewed the progress of PCOS， including heredity， predisposing genes，environmental and psychologic factors，and metabolic syndrome.

Key words: Polycystic ovary syndrome, Metabolic syndrome, Infertility, female, Genes