国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2013, Vol. 32 ›› Issue (2): 84-86.

• 论著 • 上一篇    下一篇

聚四氟乙烯涂层微型节育器对输卵管复通的影响

付正英,郭延玲   

  1. 300162 天津，中国人民武装警察部队后勤学院附属医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-03-15 发布日期:2013-03-15
  • 通讯作者: 付正英

Impact of Micro Contraceptive Device Coating with PTFE on Tubal Recanalization

FU Zheng-ying，GUO Yan-ling   

  1. Affiliated Hospital of the Chinese People′s Armed Forces Logistic College，Tianjin 300162，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-03-15 Online:2013-03-15
  • Contact: FU Zheng-ying

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摘要： 目的：研究聚四氟乙烯涂层微型节育器取出后实验动物的输卵管通畅率及复孕情况，为可复性节育器的临床应用提供实验依据。方法：采用烧结法进行聚四氟乙烯表面喷涂成形技术，制备可复性输卵管节育器。选择SPF级新西兰雌兔18只，随机分为实验组12只，对照组6只。实验组双侧输卵管均放置可复性节育器，对照组不放节育器。在节育器放置术后4，12，24周，实验组分别取4只雌兔、对照组分别取2只雌兔进行输卵管通液术，对输卵管通畅的雌兔进行复孕实验。结果：聚四氟乙烯表面喷涂成形技术工艺简单、制备方便，节育器表面光滑，具有优良的不粘性。输卵管通液21条通畅，2条通而不畅，1条不通，输卵管通畅率为95.8%（23/24）。复孕实验显示11只怀孕，1只不孕，复孕率为91.66%（11/12）。结论：聚四氟乙烯涂层微型节育器安全、可行、无不良反应，取出后输卵管恢复通畅，无明显的粘连，具有复孕功能。

关键词: 聚四氟乙烯, 避孕器械, 女用, 输卵管, 妊娠, 模型, 动物

Abstract: Objective： To observe the tubal reversal rate and re-pregnancy function after the micro contraceptive device coating PTFE was taken out. It is useful for the clinical application of this reversible contraceptive device. Methods：This recoverable fallopian tube contraceptive device was prepared using the PTFE spraying technique. Female rabbits were assigned randomly into two groups，the test group with 12 rabbits，and control group with 6 rabbits. The contraceptive devices were input in both oviducts in the test group. After 4 weeks，12 weeks，24 weeks of treatment，the contraceptive devices were removed from 4 rabbits. The hydrotubation was did，and then the re-pregnancy was tested. Results：PTFE spraying technique was simple and easy. This contraceptive device was smooth on surface. The hydrotubation test showed that there were 21 patency，2 through but no smooth，1 impatency in 24 fallopian tubes of the test group，with the patency rate 95.8%（23/24）. The re-pregnancy test showed that there were 11 pregnancy and 1 infertility，with the re-pregnancy rate 91.66%（11/12）. Conclusions：Fallopian tube recovered patency without synechia after the PTFE coating contraceptive device was removed. So this contraceptive device was safe and reliable，without adverse reaction.

Key words: Polytetrafluoroethylene, Contraceptive devices, Fallopian tubes, Pregn, Models, animal