国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2015, Vol. 34 ›› Issue (4): 312-314.

• 综述 • 上一篇    下一篇

γ-氨基丁酸及其受体与女性生殖

戴皇冠，郝翠芳   

  1. 266071 青岛大学医学院（戴皇冠）；山东省烟台市青岛大学附属烟台毓璜顶医院生殖医学中心（郝翠芳）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-07-15 发布日期:2015-07-15
  • 通讯作者: 郝翠芳

GABA and its Receptor and Female Reproduction

DAI Huang-guan，HAO Cui-fang   

  1. Medical College of Qingdao University，Qingdao 266071，Shandong Province，China（DAI Huang-guan）；Reproductive Medical Center，Yantai Yuhuangding Hospital，Affiliated Hospital of Medical College of Qingdao University，Yantai 264000，Shandong Province，China（HAO Cui-fang）
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-07-15 Online:2015-07-15
  • Contact: HAO Cui-fang

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摘要： γ-氨基丁酸（GABA）是广泛分布于哺乳动物中枢神经系统的重要抑制性神经递质。GABA及其受体还广泛存在于多种外周组织中，参与细胞间的信息传递及调控内分泌活动。近年来，大量研究证实GABA及其受体也在女性生殖过程和相关生殖疾病中发挥特异性作用。GABA信号调节卵泡发育过程中雌、孕激素的分泌，从而影响卵泡发育和成熟。同时，GABA通过与不同类型的受体结合参与胚胎植入和胎盘发生过程。此外，GABA及其受体还可通过特定的信号转导通路调控多种生殖疾病的发生、发展，并且与某些肿瘤的增殖和转移等恶性潜能有关。重点综述GABA及其受体在女性生殖生理和生殖疾病中的研究进展，并展望其在生殖领域的研究前景。

关键词: γ-氨基丁酸, 受体, GABA, 卵泡, 胎盘, 肿瘤

Abstract: GABA is a principal inhibitory neurotransmitter in the central nervous system of mammalian. However, GABA and its receptor are present not only in peripheral neuronal tissue, but also in many peripheral non-neuronal tissues, suggesting that GABA plays important roles in regulating signal transduction and endocrine function. Recently, many studies showed that GABA and its receptors also play some special roles in the female reproduction and reproductive disorders. GABA signaling is involved in follicular development and maturation by regulating estrogen and progesterone production. Meanwhile, GABA through various GABA receptors can regulate embryo implantation and placentation. In addition, GABA and its receptors are related to many reproductive diseases by some specific signaling pathways, including tumor proliferation and metastasis. This review discussed the research progress of GABA and its receptors in the female reproductive processing and related diseases.

Key words: Gamma-aminobutyric acid, Receptors, GABA, Ovarian follicle, Placenta, Neoplasms