国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (3): 251-253.

• 综述 • 上一篇    下一篇

生长分化因子9和骨形态发生蛋白15与PCOS

魏莉娜, 梁晓燕   

  1. 510655 广州，中山大学附属第六医院生殖医学研究中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-05-15 发布日期:2011-05-15

Growth Differentiation Factor 9， Bone Morphogenetic Protein 15 and Polycystic Ovary Syndrome

WEI Li-na， LIANG Xiao-yan   

  1. The Sixth Affiliated Hospital of Sun Yat-Sen University， Guangzhou 510655， China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-05-15 Online:2011-05-15

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摘要： 生长分化因子9（GDF9）和骨形态发生蛋白15（BMP15）是转化生长因子β家族的两个成员，主要由卵母细胞产生，通过旁分泌作用调节周围颗粒细胞的多种功能。研究发现，其参与卵泡发育的整个过程，对卵泡的形成和生长发育、排卵以及黄体功能都具有重要调节作用，其功能异常可能导致卵泡发育障碍。多囊卵巢综合征（PCOS）是典型的卵泡发育障碍性疾病，研究认为，其与卵巢局部生长因子作用异常有关。分析GDF9和BMP15的分子特性、表达特点、在卵泡发育过程中的作用及与PCOS的关系，对研究女性生殖生理及PCOS卵泡发育的分子机制有重要价值。

关键词: 胞间信号肽类和蛋白质类, 骨形态发生蛋白质类, 多囊卵巢综合征, 卵泡

Abstract: Growth differentiation factor 9（ＧＤＦ９） ａｎｄ ｂｏｎｅ ｍｏｒｐｈｏｇｅｎｅｔｉｃ ｐｒｏｔｅｉｎ １５（ＢＭＰ１５） ａｒｅ ｔｗｏ members of transforming growth factor β（ＴＧＦβ） family. In ovary, GDF9 and BMP15 are principally expressed in oocyte and granulosa cell. They regulate multiple functions of granulosa cells by paracrine pathway. These two factors have been shown to take part in the whole process of folliculogenesis, including the formation and progressive growth of the follicles, and ovulation. In addition, they regulate the function of corpus luteum. Their dysfunction may lead to various disorders of follicular development. Polycystic ovary syndrome （PCOS） is typical disorder of follicular development, which has been suggested to be related to the abnormal local ovarian factors. In this review， the molecular structure and expression pattern of GDF9 and BMP15, and their roles in the folliculogenesis, were analyzed. Then the pathopysiological roles of GDF9 and BMP15 in PCOS were discussed. It may improve our understanding of female reproduction and the mechanism of aberrant folliculogenesis in PCOS.

Key words: Intercellular signaling peptides and proteins, Bone morphogenetic proteins, Polycystic ovary syndrome, Ovarian follicle