国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2017, Vol. 36 ›› Issue (1): 66-69.

• 综述 • 上一篇    下一篇

microRNAs与多囊卵巢综合症发病机制的研究进展

肖华,应小燕,许波群   

  1. 南京医科大学第二附属医院
  • 收稿日期:2016-12-07 修回日期:2017-01-01 出版日期:2017-01-15 发布日期:2017-03-29
  • 通讯作者: 许波群 E-mail:boqun_xu@njmu.edu.cn
  • 基金资助:
    国家自然科学基金青年基金;国家自然科学基金

Involvement of MiRNAs in Pathogenesis of Polycystic Ovary Syndrome

  • Received:2016-12-07 Revised:2017-01-01 Published:2017-01-15 Online:2017-03-29

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摘要： 微小RNA（microRNAs，miRNAs）参与基因转录后表达调控，多囊卵巢综合征为一种异质性疾病，其发病机制尚不明确，microRNA在PCOS患者血清、颗粒细胞以及卵泡液中表达异常，提示miRNA参与PCOS的病理过程。miRNA和多种卵巢甾体激素的合成与分泌密切相关，miRNA参与卵泡的发育和闭锁从而影响PCOS患者的排卵过程，其还在PCOS胰岛素抵抗中发挥重要作用。miR-125b、miR-483和miR-320通过调控多种靶基因而影响多条信号通路。本文综述miRNAs在多囊卵巢综合征发病机制中的作用，miRNA有望成为PCOS疾病诊断和预后评估的生物学标志物，为PCOS的治疗提供新思路。

关键词: 微小RNA, 多囊卵巢综合征（PCOS）, 性腺甾体激素, 卵泡发育, 胰岛素抵抗

Abstract: MicroRNAs are able to regulate gene at the post-transcriptional level. Polycystic ovary syndrome (PCOS) is a heterogeneous disorder, the pathogenesis of which is not clear at present. Abnormal of microRNAs in serum, the follicular fluid and granulosa cells of PCOS patients might contribute to the pathogenesis of PCOS. MiRNA is closely related to the synthesis and secretion of steroid hormones.MiRNA is involved in the development and atresia of follicles and thus affects the ovulation process in PCOS patients.It also plays an important role in PCOS insulin resistance.MiR-125b, miR-483 and miR-320 affect multiple signaling pathways by regulating multiple target genes.This article reviews the role of miRNAs in the pathogenesis of polycystic ovary syndrome (PCOS), miRNA is expected to be a biological marker for the diagnosis and prognosis of PCOS disease, providing a new approach for the treatment of PCOS.

Key words: microRNA（miRNA）, polycystic ovary syndrome(PCOS), gonadal steroid hormones, follicular development, insulin resistance

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