慢性子宫内膜炎致炎机制的研究进展

doi:10.12280/gjszjk.20220294

摘要/Abstract

摘要：

慢性子宫内膜炎（chronic endometritis，CE）是病原体感染所致的慢性子宫内膜炎性疾病，与不良妊娠结局密切相关。目前关于CE的诊断和治疗尚不统一，研究CE的致炎机制有助于完善相关的诊断和治疗方法。炎症通路如Toll样受体通路和NOD样受体通路的异常激活是导致CE炎症反应发生发展的重要机制。子宫内膜免疫细胞代谢改变、微小RNA失调和DNA甲基化模式改变等机制也可通过相关通路介导炎性介质生成，参与CE的发生发展。综述CE的致炎机制，为深入认识CE的病理生理改变，寻求更规范有效的诊疗措施提供参考。

关键词: 子宫内膜炎, 信号传导, 代谢, 微小RNAs, DNA甲基化

Abstract:

Chronic endometritis (CE), a persistent endometrial inflammation caused by pathogen infection, is related to adverse pregnancy outcomes. However, there are still disagreement in the diagnosis and treatment of CE. Exploring the inflammatory mechanism of CE is helpful to improve the diagnosis and treatment of CE. The occurrence and development of CE is closely related to the activation of inflammatory pathways, such as TLR and NLR pathways. The metabolic changes of endometrial immune cells, dysregulation of microRNAs and alteration of DNA methylation patterns can abnormally regulate the generation of inflammatory mediators that are related to the pathogenesis and development of CE. The inflammatory mechanism of CE was reviewed in this article, providing a valuable information for understanding in-depth the pathogenesis and pathophysiological changes of CE, and for seeking more standardized and effective diagnostic and treatment measures of CE.

Key words: Endometritis, Signaling transduction, Metabolism, MicroRNAs, DNA methylation

熊玉晶, 罗婉彬, 艾细雄, 徐艳文. 慢性子宫内膜炎致炎机制的研究进展[J]. 国际生殖健康/计划生育杂志, 2023, 42(1): 60-65.

XIONG Yu-jing, LUO Wan-bin, AI Xi-xiong, XU Yan-wen. The Pathogenesis of Chronic Endometritis: A Review[J]. Journal of International Reproductive Health/Family Planning, 2023, 42(1): 60-65.

图/表 1

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调控通路	miRNA	所用细胞模型	靶点	功能	参考文献
TLR通路	miR-34a	BEEC	LGR4	促炎	[27]
	miR-643	HEEC	TRAF6	抑炎	[28]
	miR-505	BEEC	HMGB1	抑炎	[29]
	miR-let-7c-5p	BEEC	Ras	抑炎	[30]
	miR-424-5p	BEEC	IRAK2	抑炎	[31]
	miR-218	BEEC	MIP-1	抑炎	[8]
	miR-19a	BEEC	TBK1	抑炎	[32]
	miR-1434-5p	BESC	TBK1、CXCL5、 CXCL8、CXCL9	抑炎	[26]
	miR-200c	BESC	RelA（p65）	抑炎	[33]
	miR-1247-3p	BESC	MAPK11	抑炎	[33]
NLR通路	miR-31	BESC	IL-1β	抑炎	[26]

调控通路	miRNA	所用细胞模型	靶点	功能	参考文献
TLR通路	miR-34a	BEEC	LGR4	促炎	[27]
	miR-643	HEEC	TRAF6	抑炎	[28]
	miR-505	BEEC	HMGB1	抑炎	[29]
	miR-let-7c-5p	BEEC	Ras	抑炎	[30]
	miR-424-5p	BEEC	IRAK2	抑炎	[31]
	miR-218	BEEC	MIP-1	抑炎	[8]
	miR-19a	BEEC	TBK1	抑炎	[32]
	miR-1434-5p	BESC	TBK1、CXCL5、 CXCL8、CXCL9	抑炎	[26]
	miR-200c	BESC	RelA（p65）	抑炎	[33]
	miR-1247-3p	BESC	MAPK11	抑炎	[33]
NLR通路	miR-31	BESC	IL-1β	抑炎	[26]