国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (5): 433-436.

• 综述 • 上一篇    下一篇

影响早期妊娠药物流产结局相关因素的临床研究进展

杨毕康，侯淑萍   

  1. 200233 上海交通大学附属第六人民医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-10-25 发布日期:2016-10-25
  • 通讯作者: 侯淑萍

The Factors Related to the Outcomes of Medical Abortion in First Trimester

YANG Bi-kang，HOU Shu-ping   

  1. Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated Sixth People′s Hospital, Shanghai 200233, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-10-25 Online:2016-10-25
  • Contact: HOU Shu-ping

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摘要： 米非司酮配伍米索前列醇因其高效性、安全性以及可接受性而广泛应用于终止早期妊娠，但其临床结局中仍会出现不全流产和继续妊娠。研究发现多种因素会对药物终止早期妊娠的结局产生影响，如单用米索前列醇，米非司酮或米索前列醇给药剂量不足，米非司酮与米索前列醇序贯用药间隔时间过短，米索前列醇口服给药，妊娠时间增加或孕囊直径过大，既往生育史产次增加，既往剖宫产史，子宫前屈位或后屈位以及人为因素不恰当的干预等都将影响药物终止早期妊娠的效果，降低完全流产率。对影响药物流产结局的相关影响因素具体机制的探索，有助于临床上更加合理安全有效地用药，进一步提高药物流产的有效性和安全性。

关键词: 米非司酮, 米索前列醇, 妊娠初期, 流产, 人工

Abstract: Mifepristone combined with misoprostol has been widely applied in medical abortion for terminating first trimester pregnancy due to its effectiveness, safety and acceptability. However, there are some unfavourable problems, such as incomplete abortion and ongoing pregnancy. Several factors have been found to be related to the clinical outcomes of medical abortion, such as single misoprostol, the insufficient dose of mifepristone or misoprostol, the short interval time of two medicines, oral administration of misoprostol, the increased pregnancy time, the oversized pregnancy sac diameter, the multiple parous history, the history of cesarean section, the uterine anteflexion or retroflexion and the inappropriate intervention. Those factors related to the outcomes of medical abortion, as well as the mechanism, are discussed in this review, which is helpful for the clinic to improve the effectiveness and safety of medical abortion.

Key words: Mifepristone, Misoprostol, Pregnancy trimester, first, Abortion, induced